Any danger if you inadvertently take 2 Imbruvica 420 tabs at same time?

[Timree]

What are side affects if any when you inadvertently take 2 tabs of Imbruvica at same time?

[Zia2]

I’d call my 24 hour speciality pharmacy asap if it were me, on-call CLL specialist too if you can. What does the material read that was sent with it!?!

[gardening-girl]

Timree, in the clinical trial that led to the 420 mg ibrutinib dose, one cohort received 840 mg/day with no adverse effects, so I think that you will have no problem!

Byrd JC, Furman RR, Coutre SE, et al. Targeting BTK with ibrutinib in relapsed chronic lymphocytic leukemia. N Engl J Med 2013;369:32-42. DOI: 10.1056/NEJMoa1215637

Methods: We conducted a phase 1b-2 multicenter study to assess the safety, efficacy, pharmacokinetics, and pharmacodynamics of ibrutinib (PCI-32765), a first-in-class, oral covalent inhibitor of BTK designed for treatment of B-cell cancers, in patients with relapsed or refractory CLL or small lymphocytic lymphoma. A total of 85 patients, the majority of whom were considered to have high-risk disease, received ibrutinib orally once daily; 51 received 420 mg, and 34 received 840 mg.

Results: Toxic effects were predominantly grade 1 or 2 and included transient diarrhea, fatigue, and upper respiratory tract infection; thus, patients could receive extended treatment with minimal hematologic toxic effects. The overall response rate was the same in the group that received 420 mg and the group that received 840 mg (71%), and an additional 20% and 15% of patients in the respective groups had a partial response with lymphocytosis. The response was independent of clinical and genomic risk factors present before treatment, including advanced-stage disease, the number of previous therapies, and the 17p13.1 deletion. At 26 months, the estimated progression-free survival rate was 75% and the rate of overall survival was 83%.

nejm.org/doi/10.1056/NEJMoa...

[Blackbelt6]

I started out taking 3 dropped down to two now at one a day for quality of life. Two and three caused me bad diarrhea,Gary

[newyork8 in reply to Blackbelt6]

You mean 3 x 120mg not 3x420mg I assume.

[Blackbelt6 in reply to newyork8]

My pills are 140mg each, at least that’s what my bottle states. Gary

[Psmithuk in reply to Blackbelt6]

Welcome, Blackbelt!In your other email you say you are on Ibrutinib. Do you take that and Venetoclax?

[Blackbelt6 in reply to Psmithuk]

I only take ibrutinib

[Schubert1870]

I’m curious if one should skip the next after accidentally ingesting an extra pill.

[kathymac5252]

I think you need to contact your doctor or pharmacist....but hopefully you are drinking lots of water.....and I think our doctor told us to take the appropriate dosage at the same time the following day and not skip