Monoclonals

[Friverapt]

FDA in US has approved monoclonal antibodies for prevention of Covid infections in CLL patients

[cajunjeff]

I think what you are referring to is the recent FDA emergency use authorization for monoclonal antibody treatments for immunocompromised people.

There are criteria though. You have to have been exposed to someone with covid or you have to live/work in an institutional setting where you can’t protect against covid.

I think it’s pretty much left to our doctors to decide if we have enough proof of an exposure to qualify. I had a legit exposure a month ago and have had an infusion already a few weeks ago that I suppose is about to wear off.

fda.gov/drugs/drug-safety-a...

[johnl in reply to cajunjeff]

Jeff, I thought I heard that the monoclonal antibodies would be good for about 6 mos. why do you think they will wear off in a few weeks?

john

[cajunjeff in reply to johnl]

You can think of monoclonal antibodies as guided missiles that target and neutralize the virus, Fales says. But they don't stick around. While monoclonal antibodies are effective for about a month, they are long gone 6 months later, when a vaccine still offers significant protection.

webmd.com/vaccines/covid-19...

As I understand it, there are longer lasting antibody treatments in the works.

[bennevisplace in reply to cajunjeff]

Yes. Astrazeneca's is claimed to be good for 6-12 months astrazeneca.com/media-centr...

[1962jns in reply to johnl]

I heard they only last a month and you need a positive covid test first

[newyork8 in reply to 1962jns]

No...just exposure for those with low immunity.

[Davidcara in reply to cajunjeff]

Hope you are doing ok cajunjeff, with the hurricane and everything.

[lankisterguy Volunteer]

Hi Friverapt, -

Can you please provide a link or reference for your post?

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The only reference I can find is this: fda.gov/drugs/drug-safety-a...

Which includes these specific restrictions:

REGEN-COV may only be used as post-exposure prophylaxis for adults and pediatric individuals (12 years of age and older weighing at least 40 kg) who are:

at high risk for progression to severe COVID-19, including hospitalization or death, and

not fully vaccinated or who are not expected to mount an adequate immune response to complete SARS-CoV-2 vaccination (for example, people with immunocompromising conditions, including those taking immunosuppressive medications), and

have been exposed to an individual infected with SARS-CoV-2 consistent with close contact criteria per Centers for Disease Control and Prevention (CDC), or

who are at high risk of exposure to an individual infected with SARS-CoV-2 because of occurrence of SARS-CoV-2 infection in other individuals in the same institutional setting (for example, nursing homes or prisons)

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We have discussed this in some recent postings:

healthunlocked.com/cllsuppo...

healthunlocked.com/cllsuppo...

healthunlocked.com/cllsuppo...

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Len