Monoclonals: FDA in US has approved monoclonal... - CLL Support

CLL Support

23,339 members40,047 posts

Monoclonals

Friverapt profile image
8 Replies

FDA in US has approved monoclonal antibodies for prevention of Covid infections in CLL patients

Written by
Friverapt profile image
Friverapt
To view profiles and participate in discussions please or .
8 Replies
cajunjeff profile image
cajunjeff

I think what you are referring to is the recent FDA emergency use authorization for monoclonal antibody treatments for immunocompromised people.

There are criteria though. You have to have been exposed to someone with covid or you have to live/work in an institutional setting where you can’t protect against covid.

I think it’s pretty much left to our doctors to decide if we have enough proof of an exposure to qualify. I had a legit exposure a month ago and have had an infusion already a few weeks ago that I suppose is about to wear off.

fda.gov/drugs/drug-safety-a...

johnl profile image
johnl in reply tocajunjeff

Jeff, I thought I heard that the monoclonal antibodies would be good for about 6 mos. why do you think they will wear off in a few weeks?

john

cajunjeff profile image
cajunjeff in reply tojohnl

You can think of monoclonal antibodies as guided missiles that target and neutralize the virus, Fales says. But they don't stick around. While monoclonal antibodies are effective for about a month, they are long gone 6 months later, when a vaccine still offers significant protection.

webmd.com/vaccines/covid-19...

As I understand it, there are longer lasting antibody treatments in the works.

bennevisplace profile image
bennevisplace in reply tocajunjeff

Yes. Astrazeneca's is claimed to be good for 6-12 months astrazeneca.com/media-centr...

1962jns profile image
1962jns in reply tojohnl

I heard they only last a month and you need a positive covid test first

newyork8 profile image
newyork8 in reply to1962jns

No...just exposure for those with low immunity.

Davidcara profile image
Davidcara in reply tocajunjeff

Hope you are doing ok cajunjeff, with the hurricane and everything.

lankisterguy profile image
lankisterguyVolunteer

Hi Friverapt, -

Can you please provide a link or reference for your post?

-

The only reference I can find is this: fda.gov/drugs/drug-safety-a...

Which includes these specific restrictions:

REGEN-COV may only be used as post-exposure prophylaxis for adults and pediatric individuals (12 years of age and older weighing at least 40 kg) who are:

at high risk for progression to severe COVID-19, including hospitalization or death, and

not fully vaccinated or who are not expected to mount an adequate immune response to complete SARS-CoV-2 vaccination (for example, people with immunocompromising conditions, including those taking immunosuppressive medications), and

have been exposed to an individual infected with SARS-CoV-2 consistent with close contact criteria per Centers for Disease Control and Prevention (CDC), or

who are at high risk of exposure to an individual infected with SARS-CoV-2 because of occurrence of SARS-CoV-2 infection in other individuals in the same institutional setting (for example, nursing homes or prisons)

-

We have discussed this in some recent postings:

healthunlocked.com/cllsuppo...

healthunlocked.com/cllsuppo...

healthunlocked.com/cllsuppo...

-

Len

Not what you're looking for?

You may also like...

The anti-Covid monoclonals market hots up a bit more

This is an update to my previous post giving results for the phase 3 trial (COMET-ICE) of...

Shingrix approved

#CLL Society Shingrix approved in the US for prevention of shingles in immunocompromised adults...
bkoffman profile image
CLL CURE Hero

From the CLL14 Study: Venetoclax Plus Obinutuzumab Prolongs Progression Free Survival, Not Overall Survival , in CLL

These results, from the CLL14 study (ClinicalTrials.gov Identifier: NCT02242942), were presented at...
Jm954 profile image
Administrator

Chronic Lymphocytic Leukemia Therapy Guided by Measurable Residual Disease

From the New England Journal of Medicine 10th December 2023 "The CLL treatment landscape has...
Jm954 profile image
Administrator

ALC COUNT?

I'm really new and very confused. I just had a CBC done in the USA and i am from Canada. When you...
laldoroty profile image

Moderation team

See all
CLLerinOz profile image
CLLerinOzAdministrator
AussieNeil profile image
AussieNeilAdministrator
Newdawn profile image
NewdawnAdministrator

Content on HealthUnlocked does not replace the relationship between you and doctors or other healthcare professionals nor the advice you receive from them.

Never delay seeking advice or dialling emergency services because of something that you have read on HealthUnlocked.