Hyperbaric oxygen therapy...

[Pogee]

I just read about a trial of volunteers in Israel who took hyperbaric oxygen therapy (HBOT) for 90 minutes a day, 5 days a week, for 3 months, and the results were apparently nothing less than extraordinary in reversing the ageing process. I then briefly checked the internet and found that dating back at least as far as 2006 HBOT was considered highly promising for those with CLL (among many other issues). Generally speaking, HBOT appears to have wonderful therapeutic value for CLL, but I haven't found any scholarly articles, clinical trials, or anything else that specifically substantiate this with regard to CLL. Would anyone—calling AussieNeil!!!—have any thoughts on this?

[lankisterguy Volunteer]

Hi Pogee,

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If you haven't already, please read this Pinned Post healthunlocked.com/cllsuppo... Neil's extensive replies with many links.

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And my favorite

healthunlocked.com/cllsuppo...

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Len

[AussieNeil Partner Administrator]

It would really help if you provided references in your posts. I couldn't find anything recent on CLL related hyperbaric chamber research beyond what was covered in this referenced post from 2 years ago, in the post Len pointed you to: healthunlocked.com/cllsuppo... SeymourB provided a fairly thorough review of relevant research back then and might be interested in responding with his thoughts on the more recent research you came across.

Neil

[Pogee in reply to AussieNeil]

Sorry for being less than learned. One of the articles I saw was --researchgate.net/publicatio... -- from 2007. What I found was a real paucity of sites and information on HBOT as a possible therapy for CLL, and it surprised me considering that the field appears to be expanding rapidly.

[cllady01 Former Volunteer in reply to Pogee]

Pogee, I just looked at that site and it refers to leukemia but not to CLL. I don't understand all it says, but I wouldn't be thinking it has been helpful in any trials of any sort. It appears to be grasping at straws, much as the hype around chiropractic practice once was. Various claims are not verified by evidence.

I have had chiropractic work done for arthritis pains and muscle situations and it has been very helpful, so I don't mean there isn't a place for chiropractic work, it just apply to every ailment.

[AussieNeil Partner Administrator in reply to Pogee]

It's not about being less than learned, but saving my time. I'm one of 3 administrators managing a community of over 16,000 members and my time is much better spent reading references, rather than trying to find them. You said "Generally speaking, HBOT appears to have wonderful therapeutic value for CLL", but provided no references to support that statement. The 2006 paper you referenced in your reply is behind a firewall, but the editorial for the issue including this paper oxfordrecoverycenter.com/wp... only mentions T-cell and myeloid leukaemias, not CLL. The fairly exhaustive investigation in the post on this topic from 2 years ago, along with the lack of any new CLL specific research indicates to me that sadly, generally speaking, HBOT appears to have limited therapeutic value for CLL.

The medical news about hyperbaric research is specific to ageing, not differentially increasing apoptosis in CLL cells: medicalxpress.com/news/2020...

We get far too many encouraging news pieces in the general press about exciting cancer cures, which sadly rarely ever pan out, or take decades to do so, without adding more here, so I'm glad you've just read my post about how to determine if a study is legitimate: healthunlocked.com/cllsuppo...

Sometimes these news articles are the result of research institutes trying to attract investors. There was a big news story on Israeli cancer research in the past year or so, that did exactly that. Lots of promise of short term applicability but deeper analysis showed that it was early research.

Neil

[Pogee in reply to AussieNeil]

Good Sir: You are a shining beacon, and I sincerely apologize for causing you to respond in depth to my possibly inane posts. I will endeavor to be more careful in my posts, and to provide relevant citations. I suppose that in my ignorance I’m grasping at straws that hold little, if any, water. Let me not lead anyone astray.

[Pogee in reply to AussieNeil]

Good Sir, I just read your journal of your remarkable journey, am beyond impressed by your perseverance, and delighted to learn of your recovery. That you've dedicated your life to helping countless others is testimony to your extraordinary humanity, and beggars my ability to adequately express my deep appreciation. 😇

[CLLBGone in reply to AussieNeil]

Hyperbaric oxygen treatment: Clinical trial reverses two biological processes associated with aging in human cells

sciencedaily.com/releases/2...

.... possible therapy to rebuild a damaged immune system? Interesting article which poses more questions.

[Justasheet1 in reply to CLLBGone]

I just read through the link. No where did they mention CLL. Were you just pointing out that maybe this can keep a person young? Also, it kept the immune cells from dying. Does that include your cancerous lymphocytes too? That was the point of the clinical trial. Besides, didn’t Ponce DeLeon already discover this aka the Fountain of Youth in Florida?

😉🍻

[CLLBGone in reply to Justasheet1]

Correct they didn't mention CLL. My question involves: could this treatment possibly help fix some of the damage or immune system imbalances caused by CLL, as well as address any issues that some of the CLL treatments and their associated side efx cause? I hope study continues that could or could not validate this.

[AussieNeil Partner Administrator in reply to CLLBGone]

CLL adversely impacts the immune system through a wide range of mechanisms, per this paper: ashpublications.org/blood/a...

There's no specific mention of telomere length, though perhaps the effect of T-cell growth does leave T-cells with shorter telomeres than an age matched population.

There has been some interesting research on using CLL cell telomere length to predict progression and remission times: b-s-h.org.uk/about-us/news/...

So it might be considered possible that there could be some benefit of this research for CLL. If so, surely we would expect to observe positive improvements in CLL patients from previous hyperbaric research? Unfortunately, per the research review done two years ago, referenced in my first reply, that inprovement wasn't found.

Neil

[Pogee in reply to AussieNeil]

Thank you for your reply: as always, timely, knowledgeable, and well researched. I'm guessing we'll all keep looking for the "Holy Grail" cure.