Venetoclax and Rituximab to achieve MRD?

[Cgr2018]

My brother is on venetoclax monotherapy and he is found to start 6 cicles of Rituximab also. He is on the 400 mg dose of venetoclax now and his blood works are good. No nodes.

Its possible to have MRD in the cases of 17p tp53 cll patients with this treatment?

All of your knowledge and experiences are very helpful.

Thank you so much for your support!

[Canuck901]

I don’t know much about this combo , what works well on soneone doesn’t mean it will work the same on all cases. Venetoclax is considered the miracle drug for CLL

Your CLL specialist would know the best options available

All the best

[avzuclav]

Yes it is possible! Search up the CLL MURANO study for details (since one arm of the trial was Ven+R).

ashpublications.org/blood/a...

nejm.org/doi/full/10.1056/N...