Confused on what this means

[Carl123]

What does Unmuted with no tp53 abnormalities mean?

[SenateurDupont]

healthunlocked.com/cllsuppo...

Read this... it helped me a lot!

[Newdawn Administrator]

Carl, having no TP53 deletion is very good news. Being IGHV unmutated is less desirable than being mutated. This is how Dr. Jeff Sharman describes it;

‘In the case of CLL, the disease is divided primarily into 2 groups of patients: those who have what’s called a mutated B-cell receptor, and those who have an unmutated B-cell receptor.

In this case, mutation is good. It means you tend to have a slower growing disease, fewer high-risk genetic markers for chemotherapy resistance, and so forth. So, by looking at the IGHV [Immunoglobulin Heavy Chain Variable] mutation, or the B-cell receptor mutation status, those patients who have mutated disease are generally those patients who are going to benefit from a chemoimmunotherapy approach, whereas the patients who are unmutated are going to clearly benefit more from the novel targeted agent approach.’

In the U.K. our mutational status isn’t factored in to treatment options and only a TP53 deletion would prevent us from having chemo. However, I see you’re already looking at BTK inhibitors like Ibrutinib so your mutational status is less critical.

Hope that explains a little. Jeff’s explanation will guide you.

Newdawn

[cajunjeff]

You have a good and a bad marker for your cll, many of us have some collection of good and bad markers.

Unmutated cll is usually more aggressive than mutated cll, thats a bad marker. In your case, your TP53 gene is intact, that's a good marker. TP53 is a very important cancer fighting gene. Its not only cancer treatments that fight our cll, we have our own built in defense to help. Its a good thing to have your TP53 gene working and helping your body fight your cll cancer cells.

[Carl123 in reply to cajunjeff]

Yeh because looking at my report doesn’t mention fish test just says unmuted with no tp53 abnormalities

[littledab]

That means good news!!

[Carl123 in reply to littledab]

Thank you