Ginger ?

[vog292]

I am not familiar with ginger, but may include some ground ginger as spice in my diet. Does ginger affect CLL as medical condition ? Does ginger interfere with Imbrutinib (Imbruvica) ?

[Canuck901]

I haven’t heard ginger root being a problem for Ibruntnib. I could be wrong as your CLL specialist nurse

I know Coq10 isn’t recommend

And no probiotics while on Ibruntnib, only natural ones through yogurt or goat milk , kimchi

[MsLockYourPosts Passed Volunteer in reply to Canuck901]

Ginger can affect clotting and is on just about every list of things to be avoided with Ibrutinib. You could ask your doctor about using very limited amounts occasionally, but I wouldn't experiment on your own.

[Canuck901 in reply to MsLockYourPosts]

But how much ginger are we taking about about ? I’m sure if you had it once a week it’s fine. Daily wouldn’t be a wise idea or taking the supplements ginger root extract but having some fresh ginger root in some soup occasionally I believe wouldn’t do you any harm

[MsLockYourPosts Passed Volunteer in reply to Canuck901]

I love ginger tea, and my cardiologist OKed occasional use. I’m on Coumadin, and keeping my clotting time in range has been particularly difficult. I think that some things should be cleared by your doctor, not in an online group, as we don’t know anyone’s complete picture.

[Canuck901 in reply to MsLockYourPosts]

Where is the list ? Never seen any list with anything on it or our CLL specialist nurse and pharmacy didn’t mention anything about ginger

[starsafta in reply to MsLockYourPosts]

Can you share some of the lists you've seen that say ginger is contraindicated with Imbruvica? I can't seem to find any, and, in fact, one of the Imbruvica sites recommends ginger ale as an antidote for diarrhea.

I eat ginger all the time. If I feel a stomach upset, I eat a cube or two of crystallized ginger. I also make tea from slices of fresh ginger, turmeric, and lemon, and also from purchased tea bags.

[MsLockYourPosts Passed Volunteer in reply to starsafta]

See link farther down in the thread.

[BluMts in reply to Canuck901]

CANUCK, do you have a link to advice,articles, saying that Q10 is unadvisable with Ibrutinib?

[Canuck901 in reply to BluMts]

Apparently it’s on the B.C. Cancer website but call your CLL specialist and nurse they went over our supplements list with us and said to NOT take COq10 with Ibruntnib.

Theory is coq10 protects cells , it’s an antioxidant supplement and while you are on Ibruntnib you want to kill those bad cells.

[BluMts in reply to Canuck901]

Thanks for your reply on question about Q10. I will check as you advise.

Won't check about taking a probiotic as my Docs actually recommended it and I think it's helped me, Different cources for different horses 😉. Now that's an absolute truth.

[Canuck901 in reply to BluMts]

A probiotic isn’t recommended because you’re introducing bacteria, it not advised either . Apparently you should be eating , sauerkraut, kimchi , yogurt or goat milk as it’s a natural probiotic vs a supplement

[vog292 in reply to Canuck901]

Thank you very much for all your responses!

[Sepsur]

I believe ginger & a whole load of spices, herbs & citrus fruit are a no no - there is a list floating on a recent post

[vog292 in reply to Sepsur]

Thank you !

[Canuck901 in reply to Sepsur]

I heard Seville oranges and grapefruit are not to be consumed can cause rash, and other effects

[kaymack in reply to Canuck901]

Seville Oranges and Grapefruit juice affect the mucosa of the stomach causing increased absorption of the drug (more than the intended dose). nhs.uk/news/medication/pres...

[AussieNeil Partner Administrator in reply to kaymack]

The specific interaction is described well in the link you provided and is worth repeating here. "The authors report that grapefruit, grapefruit juice, and some other citrus fruit, including Seville oranges, limes and pomelos, contain a class of chemical called furanocoumarins. Furanocoumarins inhibit an enzyme, cytochrome P450 3A4, that is responsible for the inactivation of approximately half of all drugs.

This enzyme is found in the lining of the gut and in the liver. Furanocoumarins in grapefruit mainly inhibit cytochrome P450 3A4 in the gut.

This means that if a drug that is normally broken down by cytochrome P450 3A4 is taken at the same time as grapefruit, more ‘active’ drug will be absorbed by the body, as less will have been inactivated by the enzyme.

The prescribed dose of these drugs takes into account the fact that some of the drug will be inactivated by P450 3A4. So if this doesn’t occur, it leads to the person being exposed to higher concentrations of the drug than was intended, and this can have adverse effects.

Furanocoumarins are not present in varieties of sweet orange, such as naval or Valencia oranges."

[SenateurDupont in reply to AussieNeil]

Thanks for the info! Grapefruits has the same effect on my blood pressure meds, my Md also told me to avoid black licorice for the same reasons. And since I cannot have them, today, I crave for them! LOL

[Canuck901 in reply to Sepsur]

If you look on foods to avoid while on Ibruntnib, websites say no to grapefruit and Seville oranges , that’s it

[kaymack in reply to Canuck901]

Plus St. John's Wort.....

janssen.com/newzealand/site...

[kaymack in reply to kaymack]

Just noticed also on the Janssen sheet: Supplements such as fish oil and vitamin E preparations should be avoided.

[mrsjsmith in reply to kaymack]

Yes I was surprised by that but when I looked at the back of my omega fish oil it said not suitable for Haemophiliacs. Sadly stopped using.

Colette

[Canuck901 in reply to Sepsur]

If you look on foods to avoid while on Ibruntnib, websites say no to grapefruit and Seville oranges , that’s it

[MsLockYourPosts Passed Volunteer in reply to Canuck901]

Planetarykim just posted a very good site listing things to avoid to not Inhibit CYP 3A4. Grapefruit and Seville Oranges are just the beginning!

[Canuck901 in reply to MsLockYourPosts]

Where I don’t see it

[MsLockYourPosts Passed Volunteer in reply to Canuck901]

I'm no good with links. Click on my hub - CLL Support - members then type in her user name, Planetarykim. Then click on posts.

[Sierrastar in reply to MsLockYourPosts]

Please post this link now.

[HailMary-USA in reply to Sierrastar]

Here is the link, with thanks to PlanetaryKim:

healthunlocked.com/cllsuppo...

[mrsjsmith in reply to Canuck901]

Supplements that Inhibit CYP 3A4

[Sepsur]

herbpedia.wikidot.com/cyp3a4 - PlanetaryKim’s link. There are a lot of surprises on this list.

[MsLockYourPosts Passed Volunteer in reply to Sepsur]

Thanks, Sepsur! Computers aren't my thing.

[Sepsur in reply to MsLockYourPosts]

🤣🤣 - I do everything on my phone

[MsLockYourPosts Passed Volunteer in reply to Sepsur]

A friend recently discovered that thr reason she wasn't tolerating Imbruvica, even at the most reduced dose was that she was eating licorice.

[Sepsur in reply to MsLockYourPosts]

Yeh - I love licorice, ginger, black pepper & many of listed items.

[vog292]

I wish to thank ALL for excellent information. It benefits everybody with age-related issues and special problems to STUDY more about medicien avery day. It is also good excercise for the brain.