Double dose of imbruvica... I’m a idi... - CLL Support Assoc...

CLL Support Association
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Double dose of imbruvica... I’m a idiot!!!

Hi All,

So stupid ... I took my 3 pills of imbruvica at my normal time this evening. With out thinking 30 min later I took it again and only realized what I had done after I swallowed!!!! Yikes double dose... it’s 9:20pm in Ontario Canada. Have to work tomorrow will anything bad happen?

P.S. I’m drinking water was much as I can!

21 Replies
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Did you call the ER? Or poison control?

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I called tela health...they are supposed to call me back tonight. I left a voicemail for my oncologist.. probably won’t hear back till tomorrow.. just

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Alittle freaked out

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I would call the ER

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Thanks... appreciate your response!

I may do that if the nurse doesn’t call me back.

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I'm sorry, but whenever I talk to ER or an Urgent Care GP and mention Ibrutinib or Venetoclax I get this blank stare, and then they ask me how to spell it and use their phone to Google it.

Len

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Haha... I so understand that. I was in a pharmacy picking up the medication and the pharmacy said oh my goodness this is awfully expensive what is this for LOL

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My goodness....that was unprofessional of him!

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Does your instruction papers that come in box say anything about double dosing? Might be worth calling your doctor's service now and leave message. It should be ok. Don't panic.

If you get ill or have any major effects then go to ER.

For the future have a plan for after you take ur pills...like put back in a drawer or check off list. 💕

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I’ve been taking them for a couple years this is the first time I’ve ever double dose by accident. I think I was just tired and not thinking straight. The medication doesn’t say really what to do other than call your health provider if there is any serious side effects go to emergency. Just had wondered if anyone else had ever double dosed on imbruvica... 😢

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Hi AM75,

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I recall there was some early clinical trial testing of 420 mg vs. 840 mg and they found no difference. You can click this link:

cllsociety.org/2018/03/ibru...

"We next did a trial comparing ibrutinib 420 mg daily versus 840 mg daily in CLL patients. This trial demonstrated the same response rates and no additional toxicities at the 840 mg dose and the dose was reduced for most patients thereafter to 420 mg daily. This comparison was a small number of patients studied for a short duration at 840 mg, but many of the patients remained on 840 mg daily long-term without complications. Thus, 420 mg daily was the CLL dose taken forward."

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So IMO - I believe you should not have any problems.

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Len

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Oh that’s a relief!!! Thank you so much for responding. I’ll just keep drinking maybe another 2 L of water. Just to make sure. Hopefully telehealth will call me back and/or my oncologist tomorrow morning !

Bless you for the info!!!!!

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I don't think anything bad will happen. Just don't make a habit of it!

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I remember we had a member called Lab Rat. I am not sure what happened to him but he was on eight (?) capsules a day on the earliest clinical trial. His last post was a year ago? Maybe administrators can clarify this but he was taking about eight capsules a day for over five years and nothing happened to him.

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I put mine in a daily pill reminder so I can see if i have taken the pills or not. I set my phone alarm but am always afraid of forgetting them. Good luck, Sally

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I've done that, easily done when your memory is like mine!

I have mine in a tablet box with the days all labelled and managed to take the wrong day's tablets, then looked at it later and, because that day's tablets were still there, took them again. It was only after about an hour that I realised what I had done. :(

Nothing happened to me and I did nothing about it. Don't think I even mentioned it to anyone.

Jackie

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The reassurance you have received above I would judge is good. IF Ibrutinib was so toxic so that a double dose would be medically injurious it would not be allowed out in the public domain.

Here in the UK we have a number of poisons hotlines to call - they are amazing and have access to data about every indigestible substance.

You can also phone the drug company that makes Ibrutinib. Telephone numbers are Googlable and on the Data Info sheet in every packet.

7 hrs have elapsed since posted - morning in the UK - I hope you are OK! You should be.

Jig

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Well made it through the night after gallons of water drank ... happily I was told by the oncologist to just skip the meds today... and start again tomorrow Thank you everyone for your replies I truly appreciate it

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Glad it’s sorted! 😊

I forgot to take mine today for the first time and was a bit panicked when I realised whilst out! Now sorted. It’s easily done.

Newdawn

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Haha ... yes I am glad it was ok!

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Thanks for the follow up.

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