Zanubrutinib versus Acalabrutinib: cardiac side effects

[profrich]

I just learned of zanubrutinib. Does anyone know if it is purported to have fewer cardiac side effects than acalabrutinib? I can't find anything on line concerning this.

Thank,

Rich

[profrich]

A leading CLL researcher answered this question in email as follows:

"Yes but unclear. Less data"

[cllady01 Former Volunteer]

check out past posts by typing Zanubutinib in the search box just above Related Posts.

[MrMidnight]

I had a heart attack in 2015 after my first full round of obinutuzumab — although that treatment didn't cause it . My three main arteries were blocked and I had stents put in. I remember my haematologist saying that BGB-3111 (Zanubrutinib) was a better choice for me as a cardiology patient than Ibrutinib because it had less effect on platelets. This doesn't really answer your question because I have no knowledge of Acalabrutinib as a comparison but certainly I was told Z was better than Ibrutinib from that perspective.

[pragnar]

hematologyandoncology.net/a...