A number of people in the CLL forum seem to have the same problem. That is, they can’t tolerate 400 mg of venetoclax. However, they seem to do fine on 200 mg or even 100 mg including ALC under 1.
It seems to me that it is a good research question to ask whether anything is gained by increasing the venetoclax dosage when it only lowers neutrophils, platelets, and hemoglobin rather than lymphocyte count. I guess one would need to do flow cytometry to see if the tumor count decreases even though the ALC does not. Does anyone know if there is any research on this?