As I lie here looking at the bottle of Imbrivica my husband just picked up for me; i am in a complete meltdown. Since my CLL diagnosis 4 years ago i have chosen to forget I have the " Good Cancer " and continue to carry on with my life. Last May I started to feel the fatigue people were describing but would push thru it as my motto pre diagnosis has always been no one should be horizontal before 10pm unless your multitasking on the beach IE- relaxing and sunbathing. The past few months its been harder to deal I am constantly asking myself am I depressed or is it the CLL. If I have something that I must get up and do like go to work, or really love to do like play with my grandson I push thru and crash later. I'm guessing with depression none of that matters and I guessed correctly for when I saw y oncologist yesterday it was recommended I start treatment. I feel like such a dummy for waiting until now to think about this disease, when I read the side effects of Imbrivca they scare me as much as the disease itself. My Oncologist is considered one of the best in the USA and I did have a second opinion on the request of my family - they all seem to tout the same thing. I am again embarrassed to say that I am a Registered Nurse with years of experience but have done my best to stay away from hospitals unless I'm getting paid. I have faith in my doctor when it comes to cancer care but he repeatedly states how well people do on Imbrivica and side effects are minimal. One of my biggest fears is that 30 years ago I had two cerebral anuerysms clipped from what was believed to be a congenital defect. I'm panicked to put 2 pills in by body a day with known side effects of hemorrhage, especially when the company states on their website the cause of bleeding has yet to be understood. Add Afib/Flutter and hypertension to the list, this tells me the drug does something to arterial walls and pulmonary veins. call me crazy but if I'm predisposed to weakening of arterial walls shouldn't i reconsider this option. Also another question i have for people who take Imbrivica, from what I've read the less serious side effects of nausea, diarrhea, fatigue, rash, bruising that may only last a few months are people able to work and function normally while waiting for these to dissipate ? How about when the WBC's climb initially, are you able to be around sick people ? I am told I'll still be able to work !