I have a question that I am going to ask my CLL doctor when I see him, but I am wondering if anyone can answer. I am IGVH unmutated, which I understand is correlated with an aggressive disease. Is that true for everyone who unmutated? Or are there some sub-set of unmutated who belong to selected VH families who have an indolent disease? I understand that the mutuational status does not change. I unfortunately have a 0% mutation rate. A “family” was expressed on my IGVH test results, but I cannot recall which it is. Finally, I am wondering when CLL doctors are going to start testing us for newer prognostic markets (e.g.? NOTCH1).