Started Ibrutinib 3 months ago on the Ibrutinib/Venetoclax Trial. No side effects until start of week 8...diarrhoea. Didn't bother me at first as only once a day at my "usual time". After 3 weeks of it, it was 3-4 times a day and reflux started followed closely by nausea and then vomiting about every second day. I took loperamide for diarrhoea - one tablet 1/2 hour before each meal and one before bed, increasing dose to 2 tablets (ie taking the max of 8 tabs in a 24 hour period). This did nothing. Metoclopramide did nothing for the vomiting so I switched to cyclizine this week and I am now on ondansetron as that is meant to have a side effect of constipation. Had some mild nausea but no vomiting for a few days. Someone suggested Questran for diarrhoea (and I have noticed it mentioned on cllsociety) which I have asked trial Doc about - they will get back to me at my next appt Wed - which is when I hope to ask them about anything else I might learn here. My wcc and lymphs have dropped to almost "normal" already and last Wed I started the venetoclax, so it's all worth it - I'm 17p del so really need to be on this trial. Have lost 7kg in a month so pretty keen to get this sorted not to mention things are pretty delicate down there after 6 weeks of diarhoea. Thanks in advance for any suggestions.