I was on ibrutinib for 3 years. Other than a few side effects at the beginning, such as hair loss, joint pain, eeak nails, I successfully took 4 pills a day. Agter being off due to severe GI issues at the end, I started experiencing joint and muscle pain. This has continued to worsen since I was taken off the ibrutinib. I can't take NSAIDS because I lost a kidney earlier in my disease, but the body pain has become so severe that I mow am on heavy doses of pain meds, which simply lessen the pain a small amount. The pain interferes with my daily life. Has anyone else experienced this after being taken off ibrutinib for good? Maybe it is just coincidental, but I'm desperate to find a reason for it. I've always been in good physical shape and have never dealt with joint pain until now. It has been labeled as fibromyalgia. On the briggt side, I continue to be in complete remission with my NHL!