I've been lurking in CLLSA for about 3 years without introducing myself, mostly because I was high functioning and very active outdoors. Dx was at 50 (doc thinks I had it younger, now 54) and I'm finally at the point where I need treatment. Nodes in my neck are so swollen I can hardly swallow food, Red count 147, trisomy 12, just started losing more weight than normal last week. Extreme vertigo and now couch bound fatigue. My Onc wanted me to hold on as long as possible and now it's time. My doctor is Dr. Danilov at OHSU, he's a researcher and is putting me in a drug trial this Monday on Gazyva. Has anyone else tried this drug and what kind of side effects have you experienced? It sounds highly hopeful to return me to a very active state in a short period of time, very excited to get going on this. Thanks, sending positive thoughts to all of you in your battle, keep soldiering onward as you deal with this bizarre disease. No one understands what you are dealing with when you look normal, not even my hubby. Smile and stay strong!