Latest update on CAR-T (CTL019) personalized c... - CLL Support

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Latest update on CAR-T (CTL019) personalized cellular therapy for CLL

AussieNeil profile image
AussieNeilPartnerAdministrator
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A new study details the completed, 14-patient pilot CTL019 trial, which began in mid 2010. Four CLL patients (29 percent) in the study achieved a complete remission. All the patients in this trial had CLL that had relapsed or continued to progress after receiving multiple conventional FDA approved therapies. (These patients were running out of options!) The link below provides a good but concise summary of the trial results based on information provided by the University of Pennsylvania School of Medicine:

medicalxpress.com/news/2015...

Neil

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AussieNeil
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Justasheet1 profile image
Justasheet1

Great stuff Neil. I wish we knew their prognostic markers and mutations though.

Jeff

carnvellan profile image
carnvellan

Neil - have you seen this update?

A revolutionary leukaemia treatment could soon be approved. Here' s what it means for patients: theconversation.com/a-revol...

AussieNeil profile image
AussieNeilPartnerAdministrator in reply tocarnvellan

I haven't caught up on all recent The Conversation articles, so thanks for bringing this CAR-T update to our attention. (I edited your reply to remove what could be identifying information in the URL).

Neil

published 2015?

AussieNeil profile image
AussieNeilPartnerAdministrator in reply to

FDA approval is recent.

Cllcanada profile image
CllcanadaTop Poster CURE Hero in reply toAussieNeil

The approval was for pediatric and young adult ALL, not CLL.

medscape.com/viewarticle/88...

~chris

Searched clinicaltrials.org for CART trials. 100 in China. 63 in US. 4 in Canada - one of 4 is not actual CART but maple syrup trial...and i am not kidding.

clinicaltrials.gov/ct2/show...

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