Husband's anemia (PRCA) interrupted FCR last fall; cyclosporin worked until it was discontinued. We're looking into next treatment steps...

[LAinNYC]

any suggestions or guidance would be much appreciated!

[Cllcanada Top Poster CURE Hero]

Why was cyclosporin discontinued? Second line treatment I would look at Imbruvica (ibrutinib) as a mono therapy... but you really need to get to a CLL expert...

In NYC... Furman, Rai, Lamanna etc.

[LAinNYC in reply to Cllcanada]

Lamanna is his doc, she's been excellent...I think she wanted to see if he could maintain hemoglobin levels w/out the meds...

[bkoffman CLL CURE Hero]

Hard to stop cyclosporin used to controlled to auto-immune cytopenias. Recurrence is always a fear. Sometimes a much lower dose can be used if you slowly taper down.

[bkoffman CLL CURE Hero]

Lots of options to treat PRCA. Also knocking back the CLL can sometimes reverse the process.

[LAinNYC]

We'll talk w/doc next week, looking closer at the small molecule meds rather than more fcr if it can be obtained.

[LAinNYC in reply to LAinNYC]

Great news yesterday! Husband's hemoglobin is stabilizing (8.4!), and no transfusion is needed this week. His cyclosporine dose is slowly being increased again, and no CLL treatment is recommended for now, while the PRCA is being treated and his other blood values don't indicate the need for CLL treatment. We're both so relieved, and hope that we'll be able to access Ibrutinib when CLL treatment is again recommended.

[AussieNeil Administrator in reply to LAinNYC]

Thanks for sharing that very welcome news about your husband's improvement. You could do with some good news