Autologous CLL cell vaccination early after transplant induces leukemia-specific T cells

Autologous CLL cell vaccination early after transplant induces leukemia-specific T cells

From Eureka Alerts...

'In this issue of the Journal of Clinical Investigation, Catherine Wu and colleagues at the Dana Farber Cancer Institute in Boston report the results of a clinical trial that tested the effectiveness of vaccination with a CLL patient's own leukemia cells in the development of anti-tumor responses and relapse reduction. Patients with advanced CLL were vaccinated with their own irradiated tumor cells following allo-HSCT. Nearly 3 years after vaccination, 13 of the 18 vaccinated patients were in complete remission. The 6 patients that received the maximum vaccine dosage produced T cells that specifically reacted against tumors cells.

These results suggest that tumor cell vaccination has the potential to enhance anti-tumor responses following allo-HSCT.'

eurekalert.org/pub_releases...

FULL STUDY

jci.org/articles/view/69098...

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  • Amazing flower photo, Chris. Thank you. (Article was interesting too. Looks like good news for those who've had bone marrow stem cell transplants.)

  • Here's the Medpage Today report:

    medpagetoday.com/TheGuptaGu...

    and from Bioscience Technology.com (good detail on process)

    biosciencetechnology.com/ne...

    I'm guessing the vaccine is easier to do on a personalised basis than the CAR-T approach?

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