There are two studies that show high HDL is protective of heart disease even when LDL is elevated or Triglycerides are elevated (but not both). So if your HDL is good and your Trigs are low stop worrying.
ncbi.nlm.nih.gov/pmc/articl...
One guy has has offered £3k to antone who can produce a study that refutes this, so far no one has come up with a study
There's a lot of debate about the role of HDL, as the study noted. There's even some debate about the composition of HDL itself and how some of it may not actually play a protective role at all.
However, I think this is all a red-herring.
The most recent lipidology science states that cholesterol volume as measured by Total cholesterol and its subfractions of LDL and non-HDL, may be irrelevant.
LDL-P, or particle number, is now considered the most important determinant of CVD risk.
ncbi.nlm.nih.gov/pmc/articl...
docsopinion.com/health-and-...
peterattiamd.com/tomdayspri...
The NMR Lipoprofile blood test is the current state-of-the-science biomarker array that provides the best insight to CVD risk.
Government agencies who provide the current guidelines to front-line physicians are 20 years behind the science.
Does this study really answer how LDL enters the artery wall, I dont think so. Are there receptors for LDL connection within the artery wall again I think not which still suggests that artery damage is the main culprit and then perhaps yes more cholesterol may cause greater plaque or perhaps less stable plaque. If this is correct then I would still want to focus on damage prevention rather then cholesterol worrying
The study I cited explains the best biomarkers for determining CVD risk. What you are asking for is a separate topic. If you click on the Peter Attia link, then listen to the 5 podcasts with Thomas Dayspring and read the notes from those 5, then you may get an answer to your question.
The point of my response is to identify which biomarker is a better indicator of CVD risk. Once true risk is identified, then the patient and doctor can determine the best course of action. Damage prevention through dietary and lifestyle change is always preferable over statin therapy, without a doubt. However, doctors and patients are presently focusing on the LDL-C value as a treatment target, which is sub-optimal as I have noted and demonstrated with the links.
LDL-c goes back to 2012:
docsopinion.com/2012/11/21/...
None on it is mentioned by NHS, I am unable to find it. If NHS has no way of measuring this under their guided line, what chance do I have to get this checked?
High LDL Cholesterol all rest OK
Light Buoyant LDL versus Small Dense LDL.
