My daughter was diagnosed at age 14 with MPGN. She is now almost 23. A few years ago after a 2nd kidney biopsy, her diagnosis was changed to C3g. She was on lisinopril for years and in medical remission but developed a severe cough as a reaction to the lisinopril. She was switched to losartan. She takes it daily which lowers the proteinuria. Her specialist in NYC wanted her to go on steroids and immunosuppressants a few years ago but being of age she refused due to the known side effects and due to the uncertainty of being helped by this harsh medication regimen. She still spills a lot of protein and takes 50 mg of losartan daily. She cannot tolerate a higher dose as her blood pressure is very low from the losartan. Her kidney specialist is one of the doctors running one of the clinical trials and suggested it for her as her kidneys according to her labs are functioning normally. But I have major concerns about my daughter taking meds that haven’t been proven to stop this diseases. She also battled GI issues and has just gotten that on track through a gluten and dairy free diet. Also low sugar diet. I am thankful that this group exists because there is no one to talk to about this rare disease. The articles on the website do not give an encouraging outlook. I’m holding on to time and hope that tried meds will be on the near horizon for all those affected with C3g.