On last 28 Oct 2023 my wife stating feeling pain under the left ribs. When it persist for 3 days I went for a self ultrasound and showed to Doc. Ultrasound showed Grade 3 fatty liver, GB stones maximum size 10mm and swollen spleen. Further doc went for fibroscan. It showed 31.1 kPa. Doc directly declared it is a case of cirrhosis and further went for blood test to rule out the cause of cirrhosis. All the blood test were okay accept slight positive for Autoimmune. Doc again suggested for biopsy to get the confirmation about autoimmune and cirrhosis. However before biopsy I went for MRI which didn’t showed the cirrhosis. It again created more confusion and later we went for biopsy with a result showing consistent with cirrhosis and Autoimmune ruled out.
Now, my doc confirmed that my love has cirrhosis due to NASH and bilypsa with life style changes are prescribed.
after all this I am confused, afraid and depressed for my wife health. My 2 concerns:
A. Can it still be reversed?
B. Only bilypsa and life style changes are sufficient to stop further progress or to reverse the same.
Written by
Nawab1488
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Here is the link to information about non-alcoholic fatty liver disease (NAFLD) and Non-alcohol related steatohepatitis (NASH) on our website, which you may find useful
If you [are in the UK and] would find it useful to talk things over, our nurse-led helpline is open Monday to Friday from 9am to 3pm on 0800 652 7330 (excluding bank holidays)
We also facilitate a range of virtual support groups for people living with a liver condition (and their families and carers).
If you [are in the UK and] would find it helpful to speak to others with shared experience, you can register to join a group here
B. Only bilypsa and life style changes are sufficient to stop further progress or to reverse the same.
I think if cirrhosis is confirmed, it is rather highly unlikely. However stopping further progress (when you know the cause as in your wife case) is enough to have a good prognosis. Cirrhosis is of course serious condition but you can manage to live with it.
Thanks for your note. We are family of 3 with a 3 year old baby and believe me it is feeling like end of our world from day of diagnose. Me and my wife are suffering from a mental trauma and indefinite about my baby future. I may not be able to stand all alone 😭. I am blank.
Is there any hope in near future for cure of cirrhosis ? And why now a day people say it often reverse ?
I think "often reverse" is not true. Maybe they refer to go back to compensated state and having no symptoms? Hard to say. Also sometimes someone is diagnosed only by fibroscan result (for example has 15 Kpa). Then after it decreases (for example to 8 Kpa) it is said to be reversed. But in fact there he/she has never had F4 in the first place (no biopsy). I found this but the best is to ask your wife's hepatologist about her individual case.
"Liver biopsy is a procedure that involves taking a small sample of liver tissue and examining it under a microscope to assess the extent and severity of liver damage. Liver biopsy is considered the gold standard for diagnosing liver cirrhosis and staging its progression. Liver biopsy can also help determine the cause and prognosis of liver cirrhosis and guide the treatment options
The question of whether liver cirrhosis can be reversed is a complex and controversial one. The liver is a highly regenerative organ that can heal itself from minor injuries and regenerate new cells to replace the damaged ones. However, when the liver is exposed to chronic and persistent insults, the regenerative capacity of the liver becomes overwhelmed and the normal liver tissue is replaced by scar tissue, which impairs the liver function and structure. Once cirrhosis is established, the liver regeneration becomes very limited and the scar tissue is usually irreversible
However, there is some evidence that liver cirrhosis can be reversed or improved in some cases, depending on the cause and stage of the disease. For example, some studies have shown that patients with hepatitis B or C who achieved viral clearance with antiviral therapy had significant histological improvement and regression of fibrosis and cirrhosis
Similarly, patients with alcoholic liver disease who abstained from alcohol had reduced liver inflammation and fibrosis Patients with non-alcoholic steatohepatitis (NASH) who underwent weight loss or bariatric surgery also showed improvement in liver histology and fibrosis . Furthermore, some experimental studies have suggested that certain drugs or biological agents, such as pentoxifylline, interferon, angiotensin receptor blockers, or bone marrow-derived stem cells, may have antifibrotic effects and induce regression of cirrhosis in animal models .
However, these studies have some limitations, such as small sample size, short follow-up period, lack of standardized criteria, or conflicting results. Therefore, more research is needed to confirm the reversibility of liver cirrhosis and to identify the factors that influence it. Moreover, the reversal of liver cirrhosis does not necessarily mean the elimination of the risk of complications, such as portal hypertension or hepatocellular carcinoma. Therefore, patients with liver cirrhosis should continue to be monitored and treated according to the standard guidelines."
"However, there is some evidence that liver cirrhosis can be reversed or improved in some cases, depending on the cause and stage of the disease. For example, some studies have shown that patients with hepatitis B or C who achieved viral clearance with antiviral therapy had significant histological improvement and regression of fibrosis and cirrhosis"
Some people had HepC and had cirrhosis and in some cases quite advanced. There used to be no hope. But then pills and injections were made that cures the Hep C (and Hep B). And to a lot of peoples surprise the cirrhosis in these people went away. Point being is that if you eliminate what is harming the liver (eating bad food, drinking, the Hep C virus) great improvements can be obtained.
My suggestion to the original poster is take a deep breath, relax a bit (stress will do no good for your health) and start a healthy lifestyle campaign and see where you are in say, a year or even two years. No promises, but there have been some pretty amazing turnarounds. Don't lose hope!
Please note that I am NOT a doctor or medical professional of any kind, so feel free to ignore me if you want. Good luck in any event!
Check this article out - (its about alcohol but I dont see why the same thing cannot happen to someone whose problem was from other lifestyle issues)...
Reminds me of on this forum - when a new member asked about their life expectancy calculation (child score). Someone responded that the inquirer redo the calculation in a few years and add in the readjusted (additional years) to their life expectancy. 😅 I was thinking of that this morning.
It’s a great point. ..! Thank you to whoever wrote that.
You can’t worry about what might happen. Health issues or not. But we (as a group) are not turning a blind eye - just by our presence here on this forum. So we are all one step ahead of the general population set.
Hi Nawab, I’m sorry for your family’s current distress. It’s scary, for sure.
Focus on small steps for improvement. A lot of small steps add up to significant achievement. It takes time and is uncertain, so it’s best to concentrate on what you Can do.
I was told NAFLD Cirrhosis couldn't be reversed BUT that with diet and exercise I could keep it from getting worse. I am fortunate I don't have any other problems. I had my Gallbladder removed about 15 years ago and no problems since until this diagnosis.
Try to remain positive and do some research. keep in contact with your health professionals.
All very good comments. All I can add is I just said a prayer for you per your request. I have a long story of ups and downs. Im 100% sure without God I wouldn’t be here right now.
Hello Nawab, try not to stress and be as positive as you can for your wife and self. She is young and so am I. The most immediate thing is of course eating healthier
Im not a doctor obviously but I have spoken to many specialists. They are more willing to talk about Cirrhosis due to NAFLD and reversal than those with cirrhosis caused by alcohol which is what I have had for over two years. From what I understand from those chats is that as Ken stated, cirrhosis from Hep C and B can be reversed and cirrhosis from NAFLD can be reversed to a degree. I’m not saying all scarring will disappear but some of it supposedly can. I know getting told one thing one visit and something else in another is beyond frustrating. I honestly think diagnosing cirrhosis is art and science.
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