Anti-M2 Fusion Protein Ab 14.2 0.1 - 1.0 RATIO Liver Subtypes
Anti Sp100 Ab 12.6 0.1 - 1.0 RATIO Liver Subtypes
Anti Mitochondrial M2 Ab 9.2 0.1 - 1.0 RATIO Liver Subtypes
Gamma Glutamyl Transferase (Serum) 106 5 - 55 U/L Liver Profile (Serum)
ALT (Serum) 79 14 - 59 U/L Liver Profile (Serum)
Mean Platelet Volume 8.1 9.4 - 13.4 fL Full Blood Count
Mean Cell Volume 96.1 79.0 - 90.6 fL Full Blood Count
Can someone tell me what they mind results?
I'm not a medical professional so I wouldn't even begin to try to interpret the results. I'd suggest calling your doctor's office and asking to speak to a nurse or for one to call you and ask her to explain the results and meaning. When I was dealing with Jimmy's lab results and various tests, I'd have the nurse (because she usually had more time) what the results meant. We had My Chart so I had access to the results and it also noted what the "normal" range should be. The ones that were high or low would be marked so it was easy to find. If I didn't want to wait to speak to someone or simply to make sure I was remembering what the various ones meant, I'd copy the name of test and results and Goggle it. Then I could I could ask about any I was concerned about. I learned that some results being high or low were more concerning than others. I'm sorry that I couldn't be e more help. I'll also add that even though you can Goggle and read about the test sometimes I still didn't understand what it meant. It's ALWAYS better to speak to your nurse or doctor so you're not stressing over something unnecessarily. The first number is your result and the second pair of numbers is the normal range. If it was Jimmy, I'd call and tell them I had questions about lab results and they can either speak to you over the phone or have you come in. I'm sorry I couldn't be more help. Sharon Dixon ❤️
Your test results suggest potential issues with liver function and point toward a possible autoimmune liver condition. Here’s a breakdown of each test and what it might mean:
1. Autoimmune Liver Markers
These tests measure specific antibodies that can indicate autoimmune liver diseases:
Anti-M2 Fusion Protein Ab (14.2, elevated)
Anti-Sp100 Ab (12.6, elevated)
Anti-Mitochondrial M2 Ab (9.2, elevated)
These antibodies, especially Anti-Mitochondrial M2 Ab, are highly associated with Primary Biliary Cholangitis (PBC), an autoimmune liver disease that damages the small bile ducts in the liver.
Anti-Sp100 Ab is also seen in PBC and sometimes in overlap syndromes, such as autoimmune hepatitis (AIH).
Elevated Anti-M2 antibodies strongly suggest bile duct involvement and are very specific for PBC.
2. Liver Function Tests
These tests show liver enzyme levels and indicate whether there’s liver inflammation or bile flow obstruction:
Gamma-Glutamyl Transferase (GGT): 106 (elevated)
GGT is elevated in conditions affecting bile ducts, such as PBC, or liver stress caused by inflammation or obstruction.
ALT (Alanine Aminotransferase): 79 (elevated)
ALT is an enzyme found in liver cells. Elevated ALT suggests liver cell injury, which could be due to PBC or another liver issue.
3. Blood Count Parameters
Mean Platelet Volume (MPV): 8.1 (low)
Low MPV can suggest smaller platelets, possibly due to liver dysfunction or chronic inflammation affecting platelet production.
Mean Cell Volume (MCV): 96.1 (elevated)
High MCV (macrocytosis) could be related to liver disease or deficiencies in vitamin B12/folate, or sometimes alcohol use.
Summary of Findings
Your results strongly suggest a liver condition with autoimmune characteristics, likely Primary Biliary Cholangitis (PBC) or a related autoimmune liver disease. The elevated liver enzymes (GGT and ALT) indicate ongoing liver inflammation or damage.
Next Steps
Consult a Hepatologist (Liver Specialist):
They can confirm the diagnosis and evaluate the extent of liver involvement.
Additional Testing May Be Recommended:
Alkaline Phosphatase (ALP): Often elevated in PBC.
Bilirubin: To assess liver function and bile flow.
Immunoglobulins (e.g., IgM): High IgM levels are common in PBC.
Liver Ultrasound or Fibroscan: To check for structural changes, inflammation, or scarring.
Potential Treatment for PBC:
The standard treatment for PBC is Ursodeoxycholic Acid (UDCA), which improves bile flow and slows disease progression. If UDCA isn’t effective, other medications, like obeticholic acid, may be considered.
Vitamin supplementation (e.g., Vitamin D, calcium) may be necessary to prevent complications like osteoporosis.
Lifestyle and Supportive Measures:
Avoid alcohol and certain medications that can stress the liver.
Maintain a healthy diet rich in nutrients to support overall liver health.
Questions for Your Doctor
Do these results confirm Primary Biliary Cholangitis or another autoimmune liver disease?
What additional tests or imaging are needed to evaluate the extent of liver damage?
What treatment options are available to manage this condition and improve your liver function?
You’re taking the right steps by seeking clarification. These results can be managed effectively with proper treatment and monitoring.
Thank you for your answer. These results have been repeated for almost two years and they are always similar, it was discovered that I suffer from Lupus. I visited a dermatologist and I am visiting a rheumatologist who prescribed therapy.:
Hydroxychloroquine sulfate and Prednisolone. I live abroad and I don't think there are any experts.. Should I make an appointment with someone else, for example, a liver specialist, since as far as I know, a liver biopsy should be done to determine the severity of the disease. ps: no I do not consume alcohol at all.
Dear Radica74,
Thank you for joining our community. And thank you to our members for answering your question in such depth.
💙Andrea
