My wife and brother-in-law both have SCA 44, as did their mother. Age of onset about 60. It affects walking, hand and eye movements, speech, and hearing.
We have been looking with interest into the following: Dominant Mutations in GRM1 Cause Spinocerebellar Ataxia Type 44
"Crucially, the gain-of-function mutations could be pharmacologically modulated in vitro using an existing FDA-approved drug, Nitazoxanide, suggesting a possible avenue for treatment" Not tried yet.