SCA6 Inheritance

[SharonPS]

Does anyone know if it's possible to have the gene and not develop any symptoms?

I have older siblings who seem fine, wont have the test but are worried they might have the gene and have passed it on to their kids.

[lola261184]

I think if you have the gene you more than likely develop symptoms at some point in life. If you dont have gene you wont get it and your kids wont either.

My partner has gene but as yet has no symptoms .

[SharonPS in reply to lola261184]

My symptoms started when I was 55 and I have siblings over 60 with no symproms. How old is your partner?

[lola261184 in reply to SharonPS]

He is only 32 his nana got it at 66 his mam about 60. When did your mam have symtoms they might not have inherited the gene

[SharonPS in reply to lola261184]

I don't know when my mum started having symptoms but remember thinking she'd had some kind of stroke.

[Di-Neal]

I was 57 when I first noticed it. Your siblings are at the same risk of 50/50. It is a matter of luck.

[gossy]

I was 49 when I was diagnoised though had symptons for few years but didn't realise they were ataxia related as Dad was in his late 50s when his symptons started and most of his family were in 60s apart from one sister who was in her early 40 s my family don't want to get diagnoised as both just in early 30s

[Litty]

Unfortunately I think if you have the gene you will show it at some point and your kids may have got it off you too.

I have no proof but if you have no signs yet having trehalose works for some people - just gives me an upset tummy! Lol !

Good luck x

[FFNick]

If you have the indicator gene, then you may be the only one with symptoms in your generation. It could have missed your siblings. If They have yet to exhibit there is no way of knowing without looking for gene.

[simon22]

If you have the SCA-6 genetic defect (i.e. too many DNA 'stop' codes for a certain gene) then I'm afraid you are 100% likely to develop symptoms at some point, unless something else completely unrelated kills you first, like a heart attack or a car accident.

The average age of symptom onset is in the early 50's but there is lots of variation around this figure - many people don't experience symptoms until they're in their 60's. Conversely, some may develop symptoms earlier in their 40's.

So, those people with SCA-6 who manage to live to a 'ripe old age' will suffer from its symptoms at some point.