So I've been taking duoresp for a week now, 4 puffs twice a day. I have only needed to take my ventolin twice in a week,which for me is incredible, no bad side effects yet, my chest did hurt on the third day but it passed. Mornings are the worst time for me, I would normally be coughing and very tight chested and need 6 puffs on the ventolin and a cup of tea before being able to function but not this week. It is actually freaking me out a bit because I didn't expect any improvement for good few weeks, I'm thinking maybe it was the seretide making me bad?? One thing I have noticed is it works best if I take it 12 hours apart, 6am and 6pm. I know I'm late taking it because my chest will get tight.