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L Glutathione aerosol problems

pasquino profile image
17 Replies

Hello everyone ,

Two weeks ago I started using my nebulizer with a 5ml solution of isotonic saline with 400 mg of dissolved l-glutathione.

The problem is that it makes me cough so terribly that I have to stop after a few minutes to catch my breath, it also makes my throat sore.

I do not know if it is normal or if I have to reduce the glutathione dose, I would appreciate the opinion of those who have tried this therapy and if it has had any benefits.

I have only one lung and COPD (non serious) my age is 71, thanks in advance for your replies.

Pasquino

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17 Replies
knitter profile image
knitter

I checked it out over the internet ……side effects etc . Uses and risks .

Can you have a look too.

Did a doctor prescribe that you nebulise I-glutathione? I have never heard of it being nebulised as a standard treatment and it is a food supplement. If a doctor did prescribe it, get in touch immediately and tell them about the breathlessness. If this was not prescribed by a doctor stop it right now. Isotonic saline is safe to nebulise as it is used a lot by respiratory medicd is gentle and helps to loosen and thin mucus.

CDPO16 profile image
CDPO16 in reply to

Mt thoughts too Littlepom. I believe that it can cause bronchoconstriction as a side effect when taken orally.

in reply toCDPO16

I think that pasqwuino dissolves the glutathione in saline and nebulises it. Of course it is causing broncho spasm!. It really isn't an accepted medication. Really people shouldn't put unregulated substances such as this into already damaged lungs. As an oral product it is a food supplement, a 'therapy'. And yes, it wouldnt surprise me if taken orally it causes bronch spasm. Why, when the effective drugs available to us have been tested to destruction for patient safety, people want to put unregulated dust into their fragile lungs defeats me.

pasquino profile image
pasquino in reply to

Hi,

In reality I did this on reliable information, have a look:

The Treatment of Pulmonary Diseases and Respiratory-Related Conditions with Inhaled (Nebulized or Aerosolized) Glutathione

ncbi.nlm.nih.gov/pmc/articl...

and also:

Oral administration of GSH and NAC is convenient and safe, but they are susceptible to degradation in the digestive tract. Considering this drawback, nebulization of GSH and NAC as an adjuvant therapy may therefore be a viable alternative for the management of the early stages of COVID-19.

sciencedirect.com/science/a...

The Treatment of Pulmonary Diseases and Respiratory-Related Conditions with Inhaled (Nebulized or Aerosolized) Glutathione

hindawi.com/journals/ecam/2...

Many thans for your reply

pasquino

CDPO16 profile image
CDPO16 in reply topasquino

I doubt that it is safe to nebulise anything that hasn't been prescribed by a doctor or without medical supervision. This doesn't seem to be doing you any good pasquino and may be doing you harm in spite of what you have read.

in reply toCDPO16

Exactly.

in reply topasquino

You are looking at prospective research trials.There are thousands of these for numerous conditions and prospective treatments. They are based on conjecture and only proved when full clinical trials and licensing have taken place.. If this substance was proved in clinical trials to be safe and effective it would be an licensed treatment and a doctor would have prescribed it rather than you using on your own volition.

Krisky1 profile image
Krisky1 in reply topasquino

Actually Glutathione is nebulized quite well as it is natural to our lung lining and has shown many times to improve pulmonary function. I am an RN and have a patient recovering from Covid who has used it via nebulizer for 3 months and her x rays are remarkable. I too have asthma and have experience the very same that you have. So I decreased my dose to 250 daily and will gradually increase it I believe. But I have to use my albuterol after to relieve the spasms....so......researching....

CDPO16 profile image
CDPO16 in reply to

Yes I understood that LP. My thinking was that if it can have that side effect when taken orally it could be expected to have perhaps more potent side effects when inhaled.

in reply toCDPO16

Absolutely!

pasquino profile image
pasquino in reply toCDPO16

Hi,

To be honest , apart the cough during the process and the throat sore (temporary), the daytime and night cough has disappeared.

I guess that probably the dosage should be reduced , that`s why I was looking for advice from someone who already tried this.

CDPO16 profile image
CDPO16 in reply topasquino

I think that you may be the only one pasquino. Is it something that you feel able to discuss with your doctor to ensure it's safety?

cofdrop-UK profile image
cofdrop-UK in reply topasquino

If you are wanting to speak to someone who has experienced glutathione, there is a lady who has PCD, obviously all her life, and used to be a respiratory therapist in the USA who has experience and posts on Bronchiectasis R Us. Not sure if that is orally or nebulised. Cx

johnderby profile image
johnderby

Hi Pasquino. I agree with what the others have said. Please, just to be on the safe side, seek advice from your GP before you use it again. John

Patk1 profile image
Patk1

Are u prescribed isotronic saline?I certainly would NOT inhale anything not prescribed !!

Bronc22 profile image
Bronc22

I use Sodium Chloride Inhalation Solution USP 7% 4 mL which comes in individual vials for treatments. This comes as a sterile vial one per use. nephronpharm.com/products/s...

Used to produce sputum (mucus, or phlegm) from the mouth to help improve lung function in people with cystic fibrosis, or to collect sputum for medical testing. This medication may also be used to dilute other medications inhaled through a nebulizer.

There are several ways to use this as I have learned from Respiratory Therapist.

1st

In the hospital they use Albuterol first to open airways and calm your system down.

(Albuteral(sterile is used to prevent and treat difficulty breathing, wheezing, shortness of breath, coughing, and chest tightness caused by lung diseases such as asthma and chronic obstructive pulmonary disease )

Then they will use the 7% sodium chloride. (total of about 10 minutes or longer depending on nebulizer). This helps patients who cannot tolerate sodium chloride alone.

2nd

I have been shown to also combine both Abuterol and Sodium Chloride 7% together in nebulizer and this has proven to be tolerated for some patients. You will still cough/ expel mucus but will be less stressful.

The objective is to cause the mucus to be expelled / coughed up.

Also a good expectorant is Mucinex as a pill.

If this is available to you check out this vest :mymonarch.com/

I have never heard of L Glutathione with nebulizer. Maybe better as a digested supplement which makes more sense.

CHECK with your doctor going forward.

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