A phase III study examining whether messenger (m)RNA expression correlated with sensitivity or resistance to chemotherapy did not confer a statistically significant advantage in overall survival for patients with resected stage II-III non-small cell lung cancer (NSCLC), according to research presented at the International Association for the Study of Lung Cancer World Conference on Lung Cancer.
Lung cancer researchers and clinicians have sought methods to improve chemotherapy’s modest 5% overall survival rate for patients with NSCLC. Dr. Silvia Novello, professor of medical oncology at the University of Torino at San Luigi Gonzaga Hospital, Orbassano, Italy, and a large group of European researchers evaluated the predictive utility of the mRNA expression levels of molecular markers, mRNA expression levels of molecular markers, excision repair cross-complementing group ERCC1 and thymidylate synthase (TS).
The primary research aim of the study was to investigate if adjuvant pharmacogenomic-driven approach was able to improve overall survival in completely resected NSCLC.
