Once-daily treatment of patients with chronic obstructive pulmonary disease (COPD) with an inhaler combining fluticasone furoate (FF), umeclidinium (UMEC) and vilanterol (VI) reduced all-cause mortality by 42 percent, according to new research published online in the American Thoracic Society’s American Journal of Respiratory and Critical Care Medicine.
In “Reduction in All-Cause Mortality With Fluticasone Furoate/Umeclidinium/Vilanterol in COPD Patients,” David A. Lipson, MD, and co-authors report on an expanded post hoc analysis of data from the multicenter, 37-country Phase 3 IMPACT trial, which includes additional vital status data from patients one year after the start of the study.
This is a really important post and it would be so easy to overlook it at the moment.
I’ve just done a search to see which is the wonderful inhaler that decreases exacerbations and mortality. The inhaler contains the 3 ingredients and it is Trelegy Ellipta. I know some of our members use it.
It should not be used by people allergic to milk proteins and not for those with asthma, only COPD.
There’s a lot of info online about it.
My husband uses Trimbow which is also triple therapy but different ingredients to Trelegy. Wonder if there are any chemists who could say whether the drugs are in the same family and therefore just as effective. My husband says he’ll have a go. For anyone interested:
My partner who is newly diagnosed as moderate has been given Relvar Ellipta but it only contains two of the ingredients :- Fluticasone furoate & Vilanterol.
Umeclidinium is a muscarinic antagonist. Spiriva (Tiotropium bromide) is a muscarinic antagonist.
Done a bit of searching and the 2 triple inhalers have similar acting ingredients so may not make too big a difference which one you’re on. Trelegy now has proven record from the research you posted. Only difference is Trimbow has a muscarinic anti- cholinergic and Trelegy has a muscarinic antagonist. Not sure if that’s the same. I didn’t check the quantities but that’s for later.
Sharon’s inhaler has the corticosteroid and the LABA ( long lasting beta antagonist) NOT the muscarinic antagonist as you say.
I've been on Trelegy Ellipta for almost a year and on that time I haven't had an exacerbation . Instead I suffer badly from breathlessness . Without a doubt though life is better on Trelegy.
Yes I have been on it for over one year and find it very good was on encruse and seretide before and the respiratory nurse change me over to trelergy so only one inhaler instead of two but I like it
Content on HealthUnlocked does not replace the relationship between you and doctors or other healthcare professionals nor the advice you receive from them.
Never delay seeking advice or dialling emergency services because of something that you have read on HealthUnlocked.
Efficacy and safety of inhaler steroids in COPD patients
New drug approved in Europe for uncontrolled COPD. 
