Dr Jekyll and Mr Hyde - Enzyme targeted by TB antibiotic later stops the drug destroying it.

[2greys]

Crick and Imperial researchers have found that a key antibiotic widely used to treat drug-resistant tuberculosis does not work as expected – a finding which could be used to develop new drugs. The study was part-funded by the Francis Crick Institute and the Wellcome Trust.

The research, published in Nature Chemical Biology, found that contrary to current understanding, an antibiotic used to treat tuberculosis is unable to permanently prevent one of the enzymes it targets from functioning. By uncovering how this enzyme is re-activated, the research could lead to the development of improved versions of the drug which could be used against antibiotic resistant bacteria.

crick.ac.uk/news/2020-03-16...

[RoadRunner44]

This is a dreadful, worrying and uncertain time for us all, not knowing what may lay ahead. But, hopefully our resilliance will stand us in good stead.

Throughout this doom and gloom you are a beacon of hope! You continue to research important health issues and share your knowledge and wisdom with us unconditionally! .I know I speak for others on the forum when I say we are eternally grateful for the import you give us. I, for one, look forward to each day to see what new information you post. These little things are all going to play their part in helping us cope over the coming months.

Many people are also going to experience great disruption to their lives including financial difficulties. You have mentioned a little about your own personal problems and I sincerely hope you and others will see things through with the minimum of hardship.

So, to finish, Thank you for your regular and interesting posts. These and others on the forum will play a vital role in offering some normality to our daily lives and help to get us through these horrendous times.

Sincerely, Chrys