Antibiotic resistance by high-level intrinsic suppression of a frameshift mutation in an essential gene.

[2greys]

Tuberculosis (TB) kills at least 1.5 million people annually. A normal treatment requires four different antibiotics taken for several months. If one of the drugs does not work there is a great risk of a treatment failure. Unfortunately, antibiotic-resistant TB is now very common globally. For successful treatment it is important to quickly determine which antibiotics the TB bacteria is susceptible to. This diagnosis used to take several weeks, because TB bacteria grow very slowly. With the revolution in DNA sequencing it is nowadays possible to sequence the bacterial DNA and predict which antibiotics it will be susceptible to, all in a matter of a days.

pnas.org/content/early/2020...

[RoadRunner44]

A wonderful post TwoGreys. Many people will be benefiting by new research. A family member of mine died of TB many years ago. It makes you appreciate how far medicine has come.