Citicoline supplement

[vinsanity1525]

Does anyone have any experience or knowledge about the benefits of citicoline supplementation on AMN?

[tetris]

You seem to be the first one to mention citicoline on AMN Easier (healthunlocked.com/search/p... ).

Citicoline is neuroprotective and easily crosses the blood brain barrier, it is patented for use in ALS, and it was found to repair damage membranes in rats with multiple sclerosis.

However, increased choline intake seems to be associated with increased cancer risk.

From "Choline intake and risk of lethal prostate cancer: incidence and survival" (pmc.ncbi.nlm.nih.gov/articl... ):

> Men in the highest quintile of choline intake had a 70% increased risk of lethal prostate cancer (HR: 1.70; 95% CI: 1.18, 2.45; P-trend = 0.005).

From "The association of serum choline concentrations with the risk of cancers: a community-based nested case–control study" (nature.com/articles/s41598-... ):

> We found a positive association between elevated levels of serum choline with increased risk of incident cancer.

From "Gut Microbiome-Dependent Metabolic Pathways and Risk of Lethal Prostate Cancer: Prospective Analysis of a PLCO Cancer Screening Trial Cohort " (pubmed.ncbi.nlm.nih.gov/347... ):

> Relative to those in the first quartile, cases with the highest baseline levels of choline (Q4 OR: 2.19; 95% CI, 1.23-3.90; P-trend: 0.005) and betaine (Q4 OR: 1.86; 95% CI, 1.05-3.30; P-trend: 0.11) exhibited increased odds of developing lethal prostate cancer.

But it's hard to know if that increased cancer risk from increased choline uptake extends to citicoline supplementation, as well. Based on what we know, citicholine supplementation probably is helpful neuroprotection in people who otherwise would not live long enough to die from cancer. Because the amount of time that it takes for increased choline to increase cancer risk is maybe not as well studied, it's hard to know if supplmenting citicholine for a short period of time also increases cancer risk.

[vinsanity1525 in reply to tetris]

Thank you very much for your answer. I am now starting to doubt the use of citicoline. I think it would be better if I use only the vitamin B complex with benfotiamine 25 mg added.