Issues with Entresto

[Jishuang44]

I have dilated cardiomyopathy but also associated with it, AF and heart failure. I have just been started on Entresto as an alternative to Ramipiril (which I had been on stably for 6 months). Since starting on the Entresto I have had continual very unpleasant lip tingling and my lower face has felt (but doesn’t look) stiff and swollen.

I don’t think I can face remaining on Entresto if this is what I have to put up with all the time. What have other people’s experiences of it been? Anyone else have lip tingling etc and did it eventually go?

[Dudtbin]

I’ve been on entresto for 18 months and had no side effects at all.

[Tapanac]

my husband takes entresto and no side effects. We are told it is very good strengthening the heart

[ETFCfan]

I’ve been on Entresto for 7 months and haven’t had any side effects at all. It is meant to be the best drug for improving your heart.

[Gfern]

I have been on Entresto for the last 10 months with no side effects. What does your doctor think about your side effect in this case? I think you should discuss with your medics in case it’s something else causing your problem. Hope you get it resolved.

[Twosumsmum]

I have stopped Entresto , the cardiologist was so sure it was a miracle drug , well within a week I was so out of breath , by a fortnight so much pulmonary oedema I was reassured all would improve in 6 months, then he said I needed to increased the dose , my kidneys function bottomed out , I was all over itchy , bruising everywhere and a purple rash . I told him were to stuff the organs am back on a small increasing dose if candesartan and feel a lot better , but still at the mercy of worsening heart failure.

[theonethatgotaway1]

I have had all sorts of symptoms with entresto to begin with. It probably took 6 months on the lower dose and then around 1 year to adapt to the middle dose.

I don't recall tingling of the lips. I did get a weird lip twitching sensation.

Sides of entresto I used to get was brain fog real bad. Within an hour of taking it that lasted hours. Extreme fatigue. I'm sure it contributed to new chest pains.

[Jishuang44]

Thanks for letting me know. Maybe I should have tried for longer but I came off Entresto after 4 days as the particular side effects weren’t ones I could put up with (I already have a lot of horrible side effects with Amiadarone). I’m back on Ramipiril which seems ok other than giving me persistent reflux.