Read this on Apixaban : A major criticism of... - AF Association

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Read this on Apixaban

Vonnieruth profile image

A major criticism of the NOACs concluded that there was no way to “reverse” the blood thinning effect in patients who were actively bleeding. That particular limitation for Eliquis has now recently changed. Andexanet alfa was designed to reverse the blood thinning effects of factor Xa inhibitors. Recently, the first randomized control trial showed that andexanet alfa reversed the bleeding effects of Eliquis safely and effectively without any evidence of major side effects. Additionally in the future, four-factor prothrombin complex concentrate (4F-PCC or Kcentra) may have potential for reversing the bleeding effects of Eliquis in cases of acute bleeding or prior to emergency surgery.

7 Replies
BobD profile image

Maybe useful but lack of reversal agents has always been an excuse peple use for not taking anticoagulation. There have always been ways to treat all but life threatening trauma and nothing is instant anyway. Access to these drugs will always be limited to emergency services so don't go juggling chain saws anyway.

So does this reinforce the case for Warfarin in that is a tried and tested antidote available?

cassie46 profile image
cassie46 in reply to Ianc2

My dad was on warfarin for years and over that time was taken to A & E many times with severe nose bleeds (lasting 24 hrs) and bad bleeds from falls. Not once was he given VitK, just various forms of pressure treatment. So it does not bother me if there is no antidote.

Whoever wrote this sentence should be shot, concluded that there was no way to “reverse” the blood thinning effect in patients who were actively bleeding. It does not thin your blood, makes it sound as if the poor patient is spouting blood!


S11m profile image
S11m in reply to cassie46

I have actually seen pulsating, projectile arterial bleeding from the carotid artery - it does happen.

BobD profile image
BobDVolunteer in reply to Ianc2

Warfarin can't be reversed instantly so not in my view. I am happy with my warfarin anyway . I think the whole thing is all about people's fears . As I say emergency staff may well get supplies to carry but primary first aid is still the first line of defence.

Thats good news!xxx

I have definitely observed that since being off Plavix (anti platelet) and put on Apixaban (anticoagulant) that I no longer have had episodes of bleeding gums, or pink blood in the urine. The small cuts I have experienced all have healed rapidly while taking Eliquis. I am pleased to know however that in emergency needs Andexanet alfa will reverse the bleeding effects associated with Eliquis.

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