Hi everyone, although I have had I believe a successful ablation October 2016 as part of a trial lead by Dr Sabine Ernst at the Royal Brompton Hospital London it has not deterred my interest in this rogue condition. I look for new research all the time as I believe there is something that goes much deeper as to the reason why some of us end up with AF and others do not regardless of lifestyle.
Recently I looked at the British Heart Foundation research website and found I think something very interesting. Professor Paulus Kirchhof has been given over one million pounds to research a gene called the PITx2 .
I have pasted onto this post what I read in the BHF research website and have also looked further into other papers which are very technical which I have found on the internet regarding this gene it may be the reason why we have this condition as i have always felt that it could be gene related. It makes for very interesting reading.
This is the post by Professor Paulus Kirchhof.
The BHF has recently awarded Professor Kirchhof a Senior Clinical Research Fellowship worth £1,210,736 to bring his AF research and clinical work together and establish a world-leading research programme in Birmingham.
The research is focused on unravelling how a faulty gene may lead to AF. “We know that alterations to DNA near a gene called PITX2, which is required for development of many structures in the embryo, are linked with early development of AF and we’ve found that usually the left atrium has high levels of PITX2,” says Professor Kirchhof, who will now study why this is important, and whether alterations in the PITX2 gene can lead to AF.
Professor Kirchhof hopes that when we learn more about the different causes of AF, we may discover alternative treatments. “We have learned a lot in the last 20 years and we have tools in hand such as medication and catheter ablation to treat these electrical changes, but we need to go one step beforehand to understand why someone with a certain genetic predisposition develops AF. So we still have a lot of missing links and this is where research like this comes in.”
The impact of the research could be far reaching. Professor Kirchhof says: “I think and hope that we may be able to develop completely new ways to treat patients with this genetic predisposition once we have our insights. I’m very grateful to anyone who has donated to the BHF for their support in this important piece of research
Best wishes everyone