For the first time in something like 6 years I have begun to experience some breathlessness and fatigue, previously I have been asymptomatic. GP took me off Bisoprolol and put me on Adizem-XL instead (I also have Warfarin and Losarten). I had to stop the Bisoprolol for a few days before starting the Adizem-XL. During that time I realised the my heart rate had not increased and I felt considerably better than of late. I then began the Adizem-XL and having taken it for about a week attended surgery for a previously arranged periodic INR test. The reading was very much higher than normal (3.9). I also began to experience symptoms of stomach pain, constipation and a general feeling of "not being well". I have stopped taking the new drug and within a couple of days or so felt a lot better, a follow-up INR test gave a 2.9 result. I have been keeping a daily record of blood pressure which averages around 120/65 with an apparent heart rate between 70 and 80 bpm. I'm of the view that I don't really need a rate control drug. I wondered what other people might think? I will be going back to my GP after my next INR and will take my daily records with me.