Newly diagnosed Gleason 9 metastised pc

[Majedsh]

Hi allI'm new here

I joined beucase my husband was just diagnosed with stage 4 metastatic prostate canser Gleason 9 it's in 8 spots in the bones

What is the best treatment for his case please

[APK3]

Triplet therapy and genetic testing was what I started out with. I had just about the exact DX as your husband. Orgovyx, Nubeqa and Docetaxal was is my regiment.

[Majedsh in reply to APK3]

Thanks for the replyHope your are feeling good now

After cemotherapy what are you taking please

[APK3 in reply to Majedsh]

Orgovyx and Nubeqa.

[Majedsh in reply to APK3]

My husband will start cemotherapy next Thursday, may I ask if he can still work during the cemotherapy?

[APK3 in reply to Majedsh]

I was already retired. Depending on the job I would think if one could work or not. I believe some on this forum continued working. I was glad I was not working.

[Majedsh in reply to APK3]

Thanks for the reply

[Garbonzeaux in reply to Majedsh]

I continued to work during Chemo, but had to take a day or two off from time to time. My supervisor had had chemo before, so was very understanding about approving sick leave.

[Majedsh in reply to Garbonzeaux]

Thanks for the reply

[GP24]

This is probably the triplet therapy: sciencedirect.com/science/a...

[Majedsh in reply to GP24]

Thanks for the reply

[Tall_Allen]

Triplet therapy (Docetaxel+ADT+abiraterone/darolutamide) is now standard of care for men newly diagnosed with bone metastases.

prostatecancer.news/2021/05...

[Majedsh in reply to Tall_Allen]

Thanks

[Sunshades]

it’s important to get a second opinion from a major cancer center like Sloan Kettering or MD Anderson.

They should do testing of the biopsy specimen for genetic mutations of the cancer.

What is his PSA?

[Majedsh in reply to Sunshades]

Hi, his psa when this whole thing started was 38 on February, now it's 58!

The biopsy says its acinar adenocarinoma

Gleason9

I asked about the genetic screening of the biopsy, they saif that they will do it later

Because the tumor itself changes and any result now will be invalid in 6 months

[leo2634]

I had the same diagnosis I was put on ADT which is Hormone therapy Zytiga Prednisone and every six months an injection of Eligard I also did three Provenge infusions. My PSA was 14 at start of therapy multiple bone Mets. It's now been 8 years PSA is 0.1 since start of therapy all bone mets are stable with no progression. It does take a definite toll on your lifestyle but the key word is life. Make sure to have the most confidence in your doctor as I do that's a big factor.Never give up never surrender Leo

[Jewelrylady in reply to leo2634]

Have you ever taken a break from the meds?

[Chewiemo]

I had similar diagnosis. My triplet therapy was Lupron depot, Abiraterone (zytiga) and pluvicto (lututium 177) as part of a clinical trial. Two years in psa undetectable and scans good.

[SsgCulldelight]

Hi do a much research on your own as you can because everyone responds diffrent to treatments. Know that radiation or chemo is very aggressive and depends on how fast cells can regenerate faster than mutated cells, and side effects can seem other worldly. If he's over 65 considering overall health you may want to try ADT in its many forms, tumors or a challenge and they like to radiate those, again that treatment is VERY aggressive and difficult to recover from. Prostatectomy is good but not necessary if cancer has eluded the prostate capsule, androgen therapy can and does make cancer cells dormant reduces psa, but doesn't do anything for meets in the bones or organs, so your challenge is what to do about those Mets in the bones, hard deciding that, but quality of life is EVERYTHING so do some research get 2nd and 3rd opinions before you let them cut out burn. Light love and Good health.Ssg. Cullum

[SUPERHEAT12]

Wow. I was diagnosed with a Gleason of 5 plus 4 several years ago. I do not know what they do today, but I was fortunate to find Dr. Myers. I was on hormone treatment, radiation, and a multitude of supplements and medicines. In 2015 it came back metastized to my hip, but radiation seemed to take care of that.

[PELHA]

My husband was prescribed only doublet therapy. Because of his age and cancer said to be intermediate not aggressive we were told. I hope they were right! Anyway, if you do chemo google “hyperthermia and chemo.” This may help with symptoms and effectiveness. We have an infrared heat mat and do weekly sauna visits. It may be beneficial during treatment and at the least it feels great! Good luck.

[EdBar]

That’s the same diagnosis that I had 11 years ago, you can read my profile to see the treatments I’ve undergone over the years. I recommend that you get with an oncologist who specializes in prostate cancer and not just a general oncologist. Someone who specializes in it will be more up to speed on the latest treatment strategies. The key for me was to treat it aggressively and not mess around. That and a lot of prayers, God truly works miracles.

Ed

[Majedsh in reply to EdBar]

Thanks this give us hope God bless you

[SteveTheJ]

Get a good oncologist, one that can talk to you on your level and, more importantly, who listens to you. There are many many oncologists so if you don't find one the first time, keep trying.

You'll learn good things here but your case is different from all others so get the best advice you can for you. Look forward, never backward.

[Professorgary]

please fill your bio when convenient but until then the age and general overall health of your husband would be helpful. God bless.

[Majedsh in reply to Professorgary]

My husband is 51 years oldHis health is excellent (or this is what we thought)

And our kids are young😔

[Professorgary in reply to Majedsh]

Then I would think triplet therapy would be the optimal choice. He is young and strong enough to handle the chemo. There are side effects with these drugs so do your research. Many patients ice their hands and feet to prevent neuropathy. Also look to supplements for side effect relief. Many of us take curcumin, magnesium and berberine which really help with glucose, lipid and blood pressure increase as well as elevated liver enzymes. Google the three supplements, research their effect on each on the side effects listed and then discuss with your doctor. I was diagnosed when I was 49 years old and now I’m ready to turn 75 and am going to take my grandson trout fishing tomorrow. When I was diagnosed the treatments were very limited compared to today. Don’t be afraid to ask for a second opinion if not comfortable with your doctors advice. You got this, God bless.