Glucose

[Zavulon1945]

Hey, everybody!Strange case. Consilium of doctors, after PSMA PET CT recommended Lu177, and today, the doctor in charge of this therapy said that PSMA expression in metastasis is low. A day later scheduled an FDG PET CT scan. If it turns out that my mets( prostate removed 3 years ago) are already feeding on glucose, does that mean that it will be appropriate to abandon the berries and fruit?

[GP24]

They feed on glucose in any case, with or without berries and fruit. The FDG PET/CT is usually done to detect PSMA negative tumor. You cannot treat that with Lutetium. An alternative could be Radium223/Xofigo.

[Zavulon1945 in reply to GP24]

Thank you.🙏

[fireandice123]

Any carb is converted directly to glucose

[Zavulon1945 in reply to fireandice123]

So the fact that I've always eaten a lot of berries and fruit hasn't really affected the growth of the metastases?

[fireandice123 in reply to Zavulon1945]

That’s my view. I eat tons of berries too.

[pakb in reply to Zavulon1945]

Correct. Berries are great for you.

[Mgtd in reply to pakb]

Just finished my oatmeal with black and blueberries. See no reason to give that up unless you are really not fond of eating berries or fruit in general.

[Tall_Allen]

You can't starve cancer by limiting glucose, despite what the know-nothings on the Internet say without evidence. Cancer is fast-growing and will metabolize whatever is available, killing off healthy cells in the process.

Pluvicto only kills off the cancer that expresses PSMA (which metabolizes fats and amino acids) leaving the cancer that metabolizes glucose to proliferate.

prostatecancer.news/2019/12...

[Zavulon1945 in reply to Tall_Allen]

Thank you❤️

[Zavulon1945 in reply to Tall_Allen]

What now? No council?

[Tall_Allen in reply to Zavulon1945]

Enjoy eating, in moderation, all the foods that make life worth living.

[dhccpa in reply to Tall_Allen]

If one does a PSMA scan and an FDG scan, what does one do about the PCa cells that don't express PSMA? Abandon the idea of Pluvicto? Or simply start or continue with ADT plus Xtandi while doing Pluvicto?

Thanks.

[Tall_Allen in reply to dhccpa]

It depends on whether the non-PSMAPCa cells are discordant:

prostatecancer.news/2019/12...

[Zavulon1945 in reply to Tall_Allen]

Thanks for the link.It's really hard to weigh the pros and cons. It's hard to make a decision. I've already made so many mistakes trusting incompetent doctors.

[dhccpa in reply to Tall_Allen]

Yes, I meant they were discordant, as between the FDG results and the PSMA results.

[RobertSmith28967]

morning Zavulon

I look forward to putting a ton off berries on my porridge every morning,cancers not going to spoil that😫

[Zavulon1945 in reply to RobertSmith28967]

😂

[Eieio]

there is quite a bit of documentation and research done with metformin. To help reduce glucose and the process. But as tall, Alan stated you cannot starve. Which is not necessarily scientific, but you can reduce the glucose activity with miminic drugs as meformin or other glucose reducing or pathway interrupters. If these are of interest, there are studies with the ketogenic diet that you should cycle and not stay on. I’m doing a keto during my chemo. And it seems to be pretty effective. Halfway through I lowered carbs and my PSA has exponentially gone down with also loading oxidative stress from the chemo. But there are documented references that too much protein will also feed cancer just as well by glycolysis. So back to Alan you can’t starve cancer. But you can control input that does have a measurable good outcome. So berries are low on the glycemic index. It’s not pineapple high sugar with high volume. Feel free to PM me if you’re interested in what I’m nutritional which I don’t call therapy but functional medicine. It’s not appropriate for this forum.

[glgr in reply to Eieio]

How do I PM you?

[Eieio in reply to glgr]

Hit the chat paper airplane at the bottom menu

[fast_eddie in reply to glgr]

Click on his round daisy graphic at the top of his post and choose chat.

[85745]

Research Berberine

[mimgen in reply to 85745]

I take Berberine everyday instead of the prescription drug metformin. I also take gymnema twice a day before meals.

[Professorgary in reply to mimgen]

No disrespect, but 85745 said research it. Many people buy and take a supplement without researching it. There are many benefits but also some drawbacks. For one, it can dehydrate you because it acts as a diuretic. You need to up your water intake. And as always, discuss with your doctor. God bless.

[Zavulon1945]

Thank you. Just bought some berberine capsules. I'll start taking them in the morning.

[Professorgary in reply to Zavulon1945]

Just a note of caution. I take berberine as well because there are many studies showing the benefits, one of which is acting as a diuretic. If you are taking a diuretic for blood pressure control or edema please keep an eye on things. I was taking two 12.5mg of hctz and dropped to one a day. Also keep your water intake up and take them with a healthy fat or black pepper to increase absorption. Berberine changes the gut bacteria balance in a positive way which goes way beyond glucose control. God bless

[MateoBeach]

The FDG PET scan will show the cancer metastasis, amount and where located. This is then compared to the PSMA expressing sites. Even if SUVmax is low are still positive for some PSMA expression. The question to be answered is: Are the two in the same tumor locations (concordant), or are some FDG positive in separate locations from the PSMA positive (discordant)? If they are concordant then there could still be some favorable response to PSMA targeting treatment. Though Pluvicto may be less effective with very low SUVmax.

If the scans are discordant, then you would suspect the emergence of neuro-endocrine prostate cancer, and address that consideration. If predominantly bone mets, then discussing Radium233 in a combination such as Provenge.

In ANY event, keep up a good healthy diet to nourish body. So much that is not cancer must be supported. Keep the berries! MB

[Zavulon1945]

PSMA Test showed only two places the maximum SUV of 12 and 14. All other locations SUV 4.2 or even lower. It's all in bone metas