Radiation with Lupron side effects - Advanced Prostate...

Advanced Prostate Cancer

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Radiation with Lupron side effects

Gibronis profile image
17 Replies

Hello all. I am wondering if I could get some feedback from the group in reference to radiation therapy combined with Lupron.

Without getting into too much detail, It came back after 22 years. Grade 1 Gleason 6.

PSA was less than 0.1 until after the 10th year where it started to slowly rise. Went up and down. So from 2003 to 2025 it went from 0 to 0.4

Recent PSMA scan negative no recurrent disease .

Options are :

Keep watching it

Radiation only

Radiation with Lupron. Are there any other drugs other than Lupron to be used?

My question is how are the side effects of both Radiation and Lupron?

Finally, does anyone know if Proton Therapy is safer than the traditional Radiation?

Thanks all. :)

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Gibronis
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17 Replies
Don_1213 profile image
Don_1213

You haven't given us enough information (nor does your bio) to even begin to think about this. You stated "Recent PSMA scan negative no recurrent disease ." and then asked about radiation. Exactly what are they going to radiate?

It's been 10 years - and you're still below 2.0PSA.. (0.4?) - I again have to ask - what are they going to radiate?

If your original treatment was a RP - then the 0.4 might be some cause for concern - which at this point would probably be watching and waiting to see if it continues up, or if it was just a blip. Personally I certainly wouldn't make any sort of decision based on 1 PSA reading (and not a particularly high one even if you did RP, and insignificant if your treatment was originally radiation.) And I'd certainly want another PSA test (even if out of pocket - it's not expensive) along with a T test before even thinking about doing anything.

Photon vs Proton - no particular advantage to photon except the selling points the treatment centers like to trot out when you drop by (BTDT). Have you had any radiologist not associated with a proton center advise getting proton?

I think you're perhaps over-reacting to a number on a chart.

Gibronis profile image
Gibronis in reply toDon_1213

Thanks for your feedback I do appreciate it and really apologize if I did not give you enough info.

I asked the same question to the oncologist. He indicated the prostate bed would be radiated. I had surgery in 2003 and the PSA was zero until 2013 in which it bounced going no higher than .03. Then two recent consecutive tests 0.48 then dropped to 0.42. My urologist indicated the watch and wait approach but suggested if I wanted to see a Radiologist which I did. Again, sorry all for not giving you all the info.

Gibronis profile image
Gibronis in reply toDon_1213

The radiologist I saw was not associated with Proton Therapy. I read that Proton was less destructive on tissues. Hence my question. Thanks

Tall_Allen profile image
Tall_Allen

If it were me, I would just watch it. But you're not me, so you have to do what's right for you. My thinking is that if a bit of pattern 3 got left in the prostate bed, pattern 3 progresses very slowly, if ever (it can grow and form a tumor, but it seldom changes grade), and most (but not all) men on active surveillance with pattern 3 only, have stayed on it without grade progression for 20 years so far.

With watching, there are no side effects of radiation, but there is the anxiety of knowing something is still there.

Gibronis profile image
Gibronis in reply toTall_Allen

I appreciate your kindness and feedback. It's very confusing and stressful since after 22 years I thought I was done! How naive!

Tall_Allen profile image
Tall_Allen in reply toGibronis

I'm going on 15 years - maybe I'm naive too.

Gibronis profile image
Gibronis in reply toTall_Allen

My real concern is will it become a metastatic.

Tall_Allen profile image
Tall_Allen in reply toGibronis

I wrote this article about that:

prostatecancer.news/2017/11...

Gibronis profile image
Gibronis in reply toTall_Allen

Really! I will read! May I ask you additional questions if I have them?

Tall_Allen profile image
Tall_Allen in reply toGibronis

Of course!

Gibronis profile image
Gibronis in reply toTall_Allen

Thanks! Can I assume you have been at 0 for the last 15 years?

Tall_Allen profile image
Tall_Allen in reply toGibronis

I had radiation, so it is never at 0.

Gibronis profile image
Gibronis in reply toTall_Allen

Ah yes I see. Thanks again. I need to make a decision and its sure difficult.

Abcsoup73 profile image
Abcsoup73 in reply toTall_Allen

Good article Tall_Allen!

ron_bucher profile image
ron_bucher

Each guy's body reacts differently to the same treatment(s). For me, Lupron was a lot worse than either of my two radiation treatments. Lupron turned me into a couch potato even though I've always exercised regularly to keep in good shape, whereas with radiation alone I could do cardio exercise regularly for 90-120 minutes at a time. Radiation weakened my anal sphincter/rectum slightly but it doesn't require anything other than hitting the restroom a little sooner than I used to when the urge hits.

My first radiation was post-RP salvage radiation done without any ADT and it gave me 7.5 years of undetectable PSA.

Gibronis profile image
Gibronis in reply toron_bucher

I appreciate your feedback!

Gibronis profile image
Gibronis in reply toGibronis

If I may, how long did the Lupron effect you?

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