White Button Mushrooms

[BigTom123]

Tall Allen, any thoughts about the Japanese study indicating that white button mushrooms stop metastatic PCA?

[Tall_Allen]

I am unfamiliar with any Japanese trials on the subject. I'm only aware of an uncontrolled trial at City of Hope.

[BigTom123 in reply to Tall_Allen]

Any harm in trying it?

[Tall_Allen in reply to BigTom123]

I eat a lot of mushroom, myself.

[petrig]

I ate fresh white button mushrooms daily for a few months but then I stopped eating.I was not sure how they affect androgen receptors and what are the interactions with androgen receptor signaling inhibitor darolutamide(Nubeqa) which is one of my treatments.I tried to find studies or trials about that but did not find.So I stopped to make sure.

[Derf4223]

"In mushrooms, the dominant taste is the so-called umami taste created by sodium salts of glutamic (Glu) and aspartic (Asp) acids (monosodium glutamate (MSG)-like amino acids) and 5'-nucleotides such as 5'-guanosine monophosphate (5'-GMP), 5'-inosine monophosphate (5'-IMP), and 5'-xanthosine monophosphate (5'-XMP)."

One wonders if glutamine-avid cancer cells might like them a lot...

[Huzzah1]

I've gone through a large container of White Button Mushrooms every week for decades. Still ended up with G 9

[Mrtroxely in reply to Huzzah1]

Hah.The trials guys could have just gave you a shout.

I keep hearing cannabis cures n stops cancer....

Not my friends who died of cancer whilst, smoking and consuming it though...

[dhccpa in reply to Mrtroxely]

Yes, you can't fix a bad habit with vitamin megadoses. We often forget the things we need to stop doing, and instead think of the "cures" we can add.

[BigTom123 in reply to dhccpa]

What bad habits?

[dhccpa in reply to BigTom123]

Smoking, drinking too much, eating the wrong things, not exercising, being overweight. Whatever is bad for the body.

[BigTom123 in reply to dhccpa]

Copy that. No alcohol, weight training. Lean proteins. vegetables.

[j-o-h-n]

Note: A quick way to tell if your mushrooms are the poison ones.......Eat one and if you die, it is...........

Good Luck, Good Health and Good Humor.

j-o-h-n

[Still_in_shock in reply to j-o-h-n]

Or get Paris Mushrooms (Champignons de Paris)

Cultivated underground in horse manure.

[j-o-h-n in reply to Still_in_shock]

Sorry Monsieur, not Champignons de Paris, but Shiitake. Salutations, Chef Pierre leCS.

Good Luck, Good Health and Good Humor.

j-o-h-n

[NDJIM in reply to j-o-h-n]

Les champignons sont l'un des meilleurs aliments au monde. Nope, not an expert in speaking French…just know how to use my translator app 🤣🤣🤣. How are you doing, my friend? SOStuff, different day here in North Dakota. Colder than Blue Blazes. 🥶🥶🥶🥶. Soon, it will green up and be one of the most beautiful places on earth. Take care and keep up the light hearted postings….they make my day.

My Best, Jim

[j-o-h-n in reply to NDJIM]

Actually SSDF (Same Shit Different Flies) not SOSstuff. Doing fair to middling here in sort of cold NYC (1 inch of snow here is like a blizzard there). I bet it's beautiful there in the Spring and Summer (oil fields an exception I guess). I'll take a look on Google to view photos of that area of the U.S. (South and North Dakota and Montana). I watched the TV Netflix series "Yellowstone" and fell in love with the countryside, so I went out and bought Cowboy boots, new jeans, a saddle and a horse. Unfortunately my wife would only buy a hobby horse, so I'm skipping her for Valentine's day and giving to my girl friend instead. Gotta be careful with those wooden horses.... splinters ya know.. I'm constantly singing "I'm an old cowhand from the Rio Grande" which is now on the Gulf of America, and should have been renamed the Gringo Gulf. I wonder if President Trump will influence the amount of black gold you guys pump out of the ground? If he does you'll be working 24/7 365 and maybe time to retire when you can. Take care, and keep on pumping....

Good Luck, Good Health and Good Humor.

j-o-h-n

[NDJIM in reply to j-o-h-n]

You’re the absolute best! I’m laughing really hard right now….and you know what they say, Laughter is the best medicine. 😊. I’ll write you soon in our private email. So many cowboy stories to share…

[Graham49]

1. Is a Japanese cohort study.

2. Is a Japanese in-vitro and in-vivo study.

3. Is a phase 1 study.

4. Is a phase 2 study that may still be recruiting.

1.

Mushroom consumption and incident risk of prostate cancer in Japan: A pooled analysis of the Miyagi Cohort Study and the Ohsaki Cohort Study

Zhang, Yumi Sugawara, Shiuan Chen, Robert B. Beelman, Tsuyoshi Tsuduki, Yasutake Tomata, Sanae Matsuyama, Ichiro Tsuji

First published: 04 September 2019

doi.org/10.1002/ijc.32591

“Several limitations of our study should be noted: (i) since mushroom consumption was only assessed once at baseline, mushroom intake might have changed during follow-up; (ii) since information on mushroom species was not collected, it is difficult to know which specific mushroom(s) contributed to our findings; (iii) dietary supplements (e.g., vitamins25-27) were not considered due to data unavailability in the present study; and (iv) the exact consumption volumes of mushroom for all participants were not obtained in the present study.

In conclusion, the present prospective cohort study with long-term follow-up observed an inverse relationship between mushroom consumption and incident prostate cancer among 36,499 middle-aged and elderly Japanese men. This finding suggests that habitual mushroom intake might help to reduce prostate cancer risk. Further studies in other populations and settings are required to confirm this relationship.”

2.

White Button Mushroom (Agaricus bisporus) Disrupts Androgen Receptor Signaling in Human Prostate Cancer Cells and Patient-Derived Xenograft

Xiaoqiang WANG 1, Desiree Ha 1, Hitomi Mori 1, Shiuan Chen 1,*

PMCID: PMC8542389 NIHMSID: NIHMS1746585 PMID: 33388344

“In conclusion, through carefully designed in vitro and in vivo experiments, we showed that WBM intake affects PCa by interfering with the AR signaling axis. We also showed the antagonistic effect of the WBM component, CLA-9Z11E. The information gained from this study improves the overall understanding of how WBM may contribute to the prevention and treatment of PCa and serves as an important scientific basis for a phase 2 clinical trial using WBM on PCa.”

3.

A phase I trial of mushroom powder in patients with biochemically recurrent prostate cancer: Roles of cytokines and myeloid-derived suppressor cells for Agaricus bisporus-induced prostate-specific antigen responses

PMID: 25989179 PMCID: PMC5685188 DOI: 10.1002/cncr.29421

”Results: Thirty-six patients were treated; no DLTs were encountered. The overall PSA response rate was 11%. Two patients receiving 8 and 14 g/d demonstrated complete response (CR): their PSA declined to undetectable levels that continued for 49 and 30 months. Two patients who received 8 and 12 g/d experienced partial response (PR). After 3 months of therapy, 13 (36%) patients experienced some PSA decrease below baseline. Patients with CR and PR demonstrated higher levels of baseline interleukin-15 than nonresponders; for this group, we observed therapy-associated declines in MDSCs.

4.

White Button Mushroom Sup for the Reduction of PSA in Pts With Biochemically Rec or Therapy Naive Fav Risk Prostate CA

NCT04519879

Description:

This phase II trial studies how well white button mushroom supplement works in reducing prostate-specific antigen (PSA) levels in patients with prostate cancer that has come back (recurrent) or has favorable risk and has not undergone any therapy (therapy naive). PSA is a blood marker of prostate growth. White button mushroom supplement may affect PSA level, various parameters of immune system and levels of hormones that may have a role in prostate cancer growth.