Given an opportunity to participate in a Prostate Treatment Research Study Re : NanoKnife , at a world leading Research & Treatment Hospital -- Would you take it and why ?
In a study of focal IRE, which is largely a non-thermal form of ablation, 4/25 patients (16%) were found to have residual cancer in the ablation zone. In another study that used mpMRI to detect residual cancer up to one year after treatment, 9/30 patients (30%) were found to have residual cancer in the ablation zone. Colletini et al reported in-field treatment failures by 18% of low and intermediate-risk patients detected via mpMRI-targeted biopsy after 6 months. Valerio et al. reported that 6/34 patients (18%) had residual disease. Guenther et al. reported that the recurrence rate at 5 years was 5.6% for Gleason 6, 14.6% for Gleason 7, and 39.5% for Gleason 8–10. Gielchinsky and Lev-Cohain reported that 4/13 patients had biopsy-detected recurrence. Zhang et al. reported that 6-months after focal IRE, 46% of low- and intermediate-risk cancer still had biopsy-detected cancer outside of the ablation zone and 17% still had cancer inside the ablation zone.
""patients were under general anaesthesia with deep muscle paralysis using pancuronium bromide. Continuous peri-operative electrocardiographic monitoring with ECG was maintained... One patient [of 34] had self-resolving per-operative tachycardia requiring 24-hour inpatient surveillance "
They are "true believers," I think. I have personally talked to some. There's a good reason the FDA turned down HIFU as a treatment for prostate cancer. I think it will take a class action suit to get them to stop.
What are your thoughts on the Canadian invention at Sunnybrook Hospital in Toronto -- namely TULSA -PRO . ? ( Dr. Rajiv Chopra Inventor & founder of Profound Medical & Many other companies )
There are currently numerous trials undergoing in several countries , including in several states in the USA .
A 2021 report is old news in this fast emerging new treatment world .
Incidentially Dr. Laurence Klotz who was involved in the TULSA-PRO research team is the Lead Investigor in the Sunnybrook Trial . The downside , as with most studies . It's being funded by Profound Medical . Reminds me of : " Milk is Good for your Health "
Study funded by The Milk Marketing Board . I let the forward looking results speak for themselves To date I have not found a negative patient comment Re : NanoKnife .
Sorry, I have no idea what you're talking about re Milk. TULSA-PRO has not changed since 2021, although there are new players in the MR-targeted HIFU field (with equally poor results). The poor results speak for themselves.
I'll bet the NanoKnife patient who nearly died would have some negative comments.
I'm surprised how out of touch you are with the worldwide results .
My point with the reference to Profound Medical andThe Milk Marketing Board funfing these trials " They both had a vested interest in the results . Similarly - if a lawyer hires an expert to testify in their case . Guess what " They will testify in their favour : Why " Because the lawer iis paying his expert opion fee " .
I hope you can follow this .
I predict , that Focal Therapy is the treatment of the future with the attendant imaging etc. advances . The rest of the world is leaving the USA in the dust with respect to the advances . Immmunotherapy for example is big in other countries .
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