PSMA Imaging for Those with Compromised Kidney Function and/or for Multiple PSMA Treatments.

[cesanon]

PSMA Imaging for Those with Compromised Kidney Function

PSMA scans and treatment (including Gallium 68, Actinium, and Lutetium 177) can be dangerous for patients with compromised Kidney function.

Raul mentioned that " I know the Germans at Heidelberg have a new ligand that is metabolized in the liver and it is not eliminated by the kidneys".

The use of such an improved PSMA ligand would mean that:

(a) Those with compromised kidney function would have access to PSMA imaging and treatment, and

(b) That patients who need more than the 6 round maximum treatment limit could get those extra rounds of treatment.

Does anyone know the name of this new PSMA ligand?

[Tall_Allen]

PSMA- I & T (imaging and therapy)

pcnrv.blogspot.com/2017/09/...

[cesanon in reply to Tall_Allen]

Allen

Are PSMA- I&T (imaging and therapy), PSMA-DOTAGA and 18 F PSMA 1007 Mentioned by tango65 below, all the same ligand?

Or is 18 F PSMA 1007 different from PSMA- I&T and PSMA-DOTAGA

[Tall_Allen in reply to cesanon]

In general, the PSMA ligands that fully incorporate positron emitters into the basic molecule (like F18-DCFPyL or F18-PSMA-1007 or I-124-MIP-135) give a better signal than when a heavy metal positron emitter (Ga-68 or Cu-64 or Zr-69) is just CHELATED (loosely attached) onto molecules like PSMA-I&T (aka psma-DOTAGA), or PSMA-11 (aka PSMA-HBED-CC). There are also several ligands (e.g.,bombesin) in trials that attach to other molecules on the cancer cell. Here's a review that discusses all this:

pcnrv.blogspot.com/2016/12/...

[tango65]

18 F PSMA 1007 has minimal renal clearance and it is eliminated mainly by the liver.

ncbi.nlm.nih.gov/pubmed/292...

[cesanon in reply to tango65]

Is PSMA- I & T different from 18 F PSMA 1007?

[tango65 in reply to cesanon]

I believe they are but I am not a nuclear medicine person so I may be wrong.