Treatment question

[StaceyMac]

Hello,

My father (75) has locally advanced prostate cancer, diagnosed in Sept. He started his hormone injections but will soon have to start hormone replacement therapy (HRT) for a pituitary issue, along with steroids. My understanding from speaking briefly to one of the hospital doctors is that HRT ideally shouldn't be taken alongside the prostate hormone injections. Does anyone have any experience of what to expect treatment wise?

His original plan was hormone injections and then radiation. Cancer of prostate and surrounding lymph nodes.

Thank you for your help.

[Tall_Allen]

Which hormones? Which steroids?

[StaceyMac in reply to Tall_Allen]

We haven't got that far yet sadly, he's currently in ICU, but thankfully improving. He first cancer hormone injection was firmagon.

[StaceyMac in reply to Tall_Allen]

Possibly hydrocortisone

[Seasid]

"When managing locally advanced prostate cancer, particularly in older patients like your father, the introduction of hormone replacement therapy (HRT) alongside androgen deprivation therapy (ADT) can be complex. Here are some key points to consider:

1. Hormone Replacement Therapy and Prostate Cancer: HRT, especially if it includes testosterone, can potentially counteract the effects of ADT. Prostate cancer cells often rely on androgens for growth, so introducing additional hormones can lead to disease progression.

2. Steroids: The use of steroids can also complicate treatment. While they may help manage side effects of cancer treatment or underlying health issues, they can have various effects on the body, including potential impacts on blood sugar levels, mood, and immune response.

3. Consultation with Oncologist: It’s crucial to have a detailed discussion with your father’s oncologist. They can provide personalized advice based on his specific condition and treatment plan. They may also consider alternative approaches to managing his pituitary issue that won't interfere with prostate cancer treatment.

4. Monitoring: If HRT is necessary, close monitoring will be essential. This may include regular PSA tests and imaging to assess the impact of both the HRT and the cancer treatment.

5. Radiation Therapy: Once hormone therapy is stabilized, radiation can be a key part of treatment for locally advanced prostate cancer, especially if lymph nodes are involved.

6. Supportive Care: Engaging with a multidisciplinary team, including endocrinologists and palliative care specialists, may help manage symptoms and improve quality of life during treatment.

Overall, each case is unique, so it’s important to tailor the treatment approach based on his specific health needs and cancer progression. Encourage your father to communicate openly with his healthcare team about any concerns he may have regarding his treatment plan."

This answer is generated by the artificial intelligence application after I put your post into the ChatGPT application. You should not fully relying on the AI but you could use it to generate questions to your doctors. Always be aware that the AI can make mistakes but we humans can also make mistakes. I always double checking everything what my doctors say, just in case.

You can download ChatGPT application if you have a smartphone. If you have any questions just ask.