Interesting but still in early stages: TnpB better than Cas for gene editing

[Maxone73]

Scientists from the land of chocolate have created a smaller, more efficient gene editing tool called TnpB, which could revolutionize the treatment of genetic diseases. This protein, found in bacteria, surpasses the limitations of the CRISPR-Cas system by offering enhanced precision and delivery capabilities. In a recent study, researchers engineered TnpB to be more efficient and better at binding to DNA. They also developed an AI model to predict its editing success rate. This breakthrough was successfully used to reduce cholesterol levels in mice with familial hypercholesterolemia, showcasing its potential for treating various genetic diseases.

innovationnewsnetwork.com/g...