NOT Keytruda as a neodjuvant before RP (correction: enoblituzumab)

I've been reading about Keytruda from Merck. It's not been successful in 3 recent clinical trials for PCa but I may be invited to a new one that is assessing Keytruda as a neoadjuvant.

clinicaltrials.gov/study/NC...

I've found a few stories here about Keytruda and I see some scary side effects. But I'm willing to balance that anxiety against the hope that being involved in research like this is key for future survivors of PCa.

This is just a placeholder for now and I'll add more later if I'm enrolled.

10/1 updated: Oops, I just realized this is not Keytruda at all. But enoblituzumab. Sorry if I misled anyone.

[Tinkudi]

prayers for it to work well for you 🙏🏻.

My dad has high TMB so MO said in future would be canditate for keytruda and In his experience side effects were not much at all

[Tall_Allen]

Keytruda has bombed in almost all trials for prostate cancer, except some rare metastatic kinds. It sounds like a big risk for low probability of benefit to me.

[Tinkudi in reply to Tall_Allen]

Allen , both my MOs said they have had very good results with keytruda

[Tall_Allen in reply to Tinkudi]

1. Your father is metastatic, not localized like Hidden

2. Even in metastatic men, Keytruda has failed to be better than SOC in all but those who are msi-hi/dmmr or high TMB/PD-L1, which are extremely rare in PCa.

[Tony666]

if you are thinking of a neoadjuvant trial before RP, you may want to also explore the PROTEUS trial.

[Lightfoot550]

Hi, I take Keytruda for my prostate cancer, because my blood work showed that it might work. nothing else worked up to this point. had my prostate removed, had radiation, Ellegard and Erleada. After my first infusion of Keytruda, my PSA went from 25 down to 0.07 Have had 9 infusions so far, side effects are manageable - rash, and tiredness. There is a small percentage of prostate cancer patients that this works for. Prayers.

[TC007 in reply to Lightfoot550]

if you don't mind sharing what they look in bloodwork to decide if this gonna work or not?

[j-o-h-n]

Re: Keytruda,

Post Again! It worked for my Melanoma Lung Metastasis (not Pca). No side effects at all.

Good Luck, Good Health and Good Humor.

j-o-h-n