BAT - Testosterone Solved?

[Don_1213]

corporate.dukehealth.org/ne...

Looks like a really interesting study, and implies that reducing T during early cancer stages is a good thing, but it may not be a good thing in advanced PCa later - and actually, increasing T (high doses) may do more good.

"DURHAM, N.C. – A treatment paradox has recently come to light in prostate cancer: Blocking testosterone production halts tumor growth in early disease, while elevating the hormone can delay disease progression in patients whose disease has advanced.

The inability to understand how different levels of the same hormone can drive different effects in prostate tumors has been an impediment to the development of new therapeutics that exploit this biology.

Now, a Duke Cancer Institute-led study, performed in the laboratory of Donald McDonnell, Ph.D. and appearing this week in Nature Communications, provides the needed answers to this puzzle. "

The article: nature.com/articles/s41467-...

[Broccoli24]

I saw that too… very interesting… let’s hope we see some quick follow up research to make it more than a theory!

[Jac_J]

Thanks. Very interesting and imo this approach may be validated in a few decades.

ATM there is a financial disincentive (by pharmaceuticals) and an extreme risk adverse approach exhibited by the medical profession which will inhibit the uptake of this approach.

[Justfor_ in reply to Jac_J]

Without any knowledge of what monomers and dimers/oligomers are and how they are biologically "hard wired", but only knowing how the power grid behaves, 3 years ago I embarked on a N=1 experiment of adaptive Bicalutamide that up to now works exceptionally good. The published paper, regarding the part of the non-linearity at the point where the monomers-dimers repopulate, gives me a hint related to the PSA high volatility around the equilibrium (my term) point I have been noticing in my case.

[j-o-h-n in reply to Justfor_]

Ταραγμένος..........

Good Luck, Good Health and Good Humor.

j-o-h-n