observable versus actual metastasis explained

[Darryl]

Please let me know if this kind of short information video is helpful. There was a brief discussion about observable versus actual metastasis during (I think) the last day or two, so I took that as a topic to see how our community responds to this kind of video. Would more of these on basic concepts interest you?

youtu.be/LjtNg_RrJUs(Not working as expected?)

[janebob99]

I give it a B+. Very good first attempt. Some negative comments are:

1. It's about 25% too long. Too much repetition.

2. The speaker needs to narrate the slides precisely and not add extra words or sentences.

3. The video should mention that some tumors will be not be observed because they are too small and are below the detection limit.

Who is the speaker? His voice sounds familiar.

Otherwise, a very helpful and interesting educational video.

[vintage42]

Short, informative and I marked it. Made me appreciate the importance of ADT against actual undetectable mets.

[dhccpa]

Pretty good.

How about one on Castrate Resistance and how it is determined and when?

Doctors seem to differ with each other in their understanding and usage of many of the simple terms we throw around on the forum every day.

But it was short and sweet, which I like. I normally hate videos as a source of important information, but this was fine.

[jackwfrench]

Agree w dhccpa.

[Mascouche]

Thanks for the video.

In the set of slides that show "What is metastasis?" at around the 1st minute of the video, there are three bubbles of information. The right-most one is the "process overview" and the left bubble is the "Definition". But the middle bubble is a copy of the left bubble to which an extra period was added at the end. Should there have been another bubble in the middle?

[Darryl Partner in reply to Mascouche]

Good catch. Thanks! The joys of a quickly cobbled rough draft. There should have been only two "bubbles" on that slide. I'll delete this in a couple of days. I want to see if this format is appetizing and informative.

[mababa]

Daryl, I thought the short video presented a succinct and easy to understand description of metastasis. I’ve been dealing with metastatic PCa for about 10 months and have at times been overwhelmed by the complexity and quantity of medical terminology presented to me. This very short video helped remind me about what exactly I’m having to battle and to know that going after the “visible” cancer is just the start of treatment—that metastasis means my PCa was circulating throughout my body well before growing to a detectable size in my lymph nodes. It will very likely reappear post radiation therapy, but, hopefully, not for several years.

[NanoMRI]

Is this format appetizing and informative? Helpful? I would say definite yes. Not too long, no hype, easy to read/understand bullet points.

IMO a critical question is does this presentation adequately drive home the critical distinction that 'actual metastasis' is happening before it becomes 'observable'? (one reason why I think 'undetectable' is such a dangerously misleading term).

Just last week had my third PSMA PET and blood biopsy testing since my PSA rose into the 0.03X range three years ago (I do bimonthly PSA testing). I have no doubt actual cancer cells remain and I am doing all I can to identify ASAP if/when the transition from "actual metastasis" to "observable metastasis" occurs. I no longer want to give this beast time and obscurity.

[Darryl Partner]

I see that this video needs a rewrite so it's crystal clear. That's one of the benefits of this format. Relatively easy to create and relatively easy and quick to revise/redo. It's good for me to hear how well (or not) this format works. I've tried several other formats in the past that were not liked by our community. There's another, more involved format that I'm "testing" privately, as it involves videos actually showing the speaker and not just their voice. So far, reviews for that are super, too.

[garyjp9]

Hi Daryl, I agree that this format and content is very helpful. One question I have is whether a liquid biopsy can detect actual metastases even before they are observable?

[addicted2cycling]

Thanks for posting

👍👍

Bring on more 😊

[Mgtd]

Really enjoyed this format. I was going to suggest that if this was going to be a series that you would start with diagnosis tools followed by potential solutions, etc. That way a person could follow and get pre briefed on what to expect. Keep them short!

Thanks for doing this. I see a lot of potential in these.

[Cooolone]

Well, for an advanced patient that is already in the mix, it is akin to being served Chicken Soup that has no flavor.

Basically a dictionary explaining what terms mean, but lacking depth, no explanation of what is actually happening. Intravascular or Extravascular activity as an example... HOW?

The "actual" metastatic activity requires more depth, it is a fascinating world, much still not understood, but is worth diving in the pool for those interested, ie, of what currently is (understood).

All in all, a nice introduction for those maybe newly entering the world of advanced PCa. But leaves much to the imagination. Filling in the blanks will make it much more educational.

Information is always useful and interesting to those who want to dive into the pool of knowledge. A video series sectioning off each segment (from the video above) and getting more in depth would be invaluable to those wanting it. But avoiding bias will be difficult as the field expands and moves so rapidly these days, by the time a script is created, shot, edited and published, it can already be old news by the time the targeted audience see's it.

So what to do? What to do?

The effort is appreciated nonetheless!

All the Best

[CAMPSOUPS in reply to Cooolone]

Agree. A deep dive into bone metastasis for us that have such is very enlightening. This was as you said a introductory type of video.

I like to understand the whole process and the effects of treatment on it. Get into the weeds on sclerotic metastases' which is primarily what most of us have. And of course lytic metastases' which we would not want but I for example had one noted about 6 months ago. A change in my widespread sclerotic metastasis.