PSA from .08 to 2.1, after 2yrs ADT with zytiga and RT @59 yr

[Eieio]

so seems to be back and waiting on PSMA PER SCAN. From what I understand, they usually look for something and do a scavenge RT treatment. Anyone who’s gone through this did you have to go back on ADT because that just sucks.. I had high risk Gleason score 9 anybody deal with this? I’m sure. Let me know your story and how it worked out or if it did or not also gas anyone tracked theses white button mushroom studies it seem to be a channel blocker for PSA increasing essentially stopping the tumor from growing. Literally white mushrooms off the shelf and an extract and seems to stop progression?

[TylexGP]

Wish I could be of more help. I am a year behind you. PSA 0.05 Had EBRT and HDR Brachytherapy and 2 years of ADT with Lupron and Abi. Have you had genetic testing done?

[Eieio in reply to TylexGP]

Yes they ran the genetics when it first was diagnosed, I am assuming that is what they will use to plan the next steps. If anyone else is reading this , I have heard the a changing up the ADT to be intermittent. I’m not sure if that’s true but studies are coming back showing no conclusive evidence that ADT had a full cycle or intermittent is better. So just fishing here to see what others have done.

[Tall_Allen]

The reason for the PSMA PET scan is to rule out distant metastases. If there are distant metastases, there is no point in going through salvage radiation.

If no distant metastases, it's a good idea to have an mpMRI too, and, if a local recurrence, a biopsy. If not local, the only other possibility is a regional recurrence. For a regional recurrence, you will need radiation to the pelvic lymph node area and hormone therapy for 2-3 years.

[vintage42 in reply to Tall_Allen]

"... If there are distant metastases, there is no point in going through salvage radiation... For a regional recurrence, you will need radiation to the pelvic lymph node area and hormone therapy for 2-3 years."

That describes me. Radio-recurrence in prostate, but mets to one pelvic and one abdominal node, so no salvage radiation to prostate. Had pelvic radiation, and went on hormone therapy with Orgovyx and Abiraterone, a very easy combination for me.

[Eieio]

very sound advice. I thank you for the information especially the mpMRI. I had some indication on the lymph’s not a lot but affected. I’m wondering if there is an alternative to ADT because that just about ruined me after two years. Lupron and zytiga from the start. I stopped at a year ago and just started feeling and looking normal again. I’ve seen some research trials on white button mushroom channel blocker or dna “something” , and high dose antioxidant therapy, there’s a mix of some compounds in addition that promote normal cell apoptosis, could be wrong, but I think the function is to force a cancer cell into aptosis. I guess that’s the function. I don’t know the validity of any of those types of treatment and if there’s real data on it or it’s still an exploratory subject.

[Tall_Allen in reply to Eieio]

If your lymph nodes are enlarged, they need treatment. There are no alternatives to hormone therapy.

There is no data on mushrooms that would enable you to use them as therapy. Be careful about antioxidants with radiation as they negate what radiation does.

Here's the mushroom trial:

clinicaltrials.gov/study/NC...

[Eieio in reply to Tall_Allen]

Sorry I was not clear and specific about the lymph's. At initial diagnosis there was indications that it had spread locally to one of lymph’s. So that was in the RT treatment plan. I used photon not proton on the first radial treatment. Since I haven’t had my PSMA pet scan yet it is too early to predict the future treatment. However I am considering the proton option since it has not exit scatter at the target site to cause further damage. my concern has been low red and white CBC counts because of the prior radiation with ADT dropping the testosterone.

[treedown]

I had radiation, 2 years ADT, recurrence after about 1 year. Back on ADT. I eat a lot of white mushrooms as well as few other types. Also, concentrated mushrooms in drinks. This July is 5 years from dx. I have read some info on white button mushrooms but would never consider them a replacement for ADT and Zytiga. In the end its your choice what you see want to do but wait until all the test and scan results are in and have heard what your doctors recommend before you commit to anything.

[SViking in reply to treedown]

on the white bush button mushrooms matter, cooked or uncooked and how many? I was eating them raw in an organic mixed greens salad, but then started reading that you got more of the critical nutrients when they were cooked.

[treedown in reply to SViking]

I read that as well about cooked but eat them raw quite often. I couldn't say how much but very little of the food I make doesn't have mushrooms in it. Often 4 types or more. I have access to quite a variety where I live.

[j-o-h-n]

Greetings Eieio,

It's nice so see another farmer/singer who has joined the group. Would you be kind enough to add pertinent data to your bio? I.E.(Location? Treatment center(s), doctor(s) name(s)? Meds? Psa score(s)?, Dates? Crops?, Farm Animals? and etc.). All info is voluntary but is helpful to you and to us. Thank you!

Good Luck, Good Health and Good Humor.

j-o-h-n

[Eieio]

so PSA went 2.1 to 2.9 in less than a month, PSMA pet scan showed lymph area missed in the first window and 1 bone met on the C2. MO says back to the RO to plan more IMRT then immediate change from zytiga stopped almost 2 years ago to xandti. And eligard. That ADT just sucks. Anyone have this situation , my mistake on the first round of ADT was not weightlifting hard and serious excersize. I’m looking to see if there’s an intermittent holiday possibility after 9 months to look and see. 2 more years is not something I want to repeat. Since it’s was only 1 bone met the MO seems optimistic I’m still in the window of curative if they can get the few areas that lit up in the pet scan.

[PSAed in reply to Eieio]

Thanks for the update, and it does have pretty good news in that you are still in with a shot of a cure despite the price being more ADT. My own PSA has shown increases in the last three tests, that's after "curative intent" treatment that finished June2022 ie RT/HT. No argument from me on the SE's of ADT!! I still hope.

[Eieio]

yes it seems like PSA of 2.0 or greater is the call for a pet scan or doubling time. Thanks for the reply, I’m really hoping they hit it all on this next round. I don’t know how these guys do years of it. Not a choice I guess.