Initial Phase 1 Data on MB-105 for Patients with PSCA-positive Castration Resistant Prostate Cancer

[Maxone73]

From what I understand PSCA is highly expressed in prostate cancer cells but also in other kinds of cancer and also in other tissues (in small amounts), and its production increases as the disease progresses, making it a better target for later stages (but this is my speculation!).

What is important is that we have another good target for therapies!!

About the other part, the CAR T cells part, I will copy/paste here:

"In a 73-year-old male patient with PSCA-positive mCRPC who was treated with MB-105 and lymphodepletion (a standard CAR T pre-conditioning regimen) after failing eight prior therapies, MB-105 demonstrated on day 28 a 94 percent reduction in prostate-specific antigen (PSA), near complete reduction of measurable soft tissue metastasis by computerized tomography, and improvement in bone metastases by magnetic resonance imaging."

theglobeandmail.com/investi...

[God_Loves_Me]

Any recent FDA treatment approval in 2024? How do you find newly available clinical trials, I am not able to sorting on clinical portal

[Maxone73 in reply to God_Loves_Me]

fda.gov/drugs/resources-inf...

if it's not under "prostate" it could be under "solid tumors"

to find the clinical trials I use clinicaltrials.gov but I also search on Google and sort them by date, as not all the trials are on clinicaltrials.gov. Also business pages (suggesting to invest in biotech and pharma) are a great source.

[God_Loves_Me in reply to Maxone73]

I am sorry i do not mean to change the topics, I like to learn from you so asking you different questions. Do you also monitors new clinical trial and approved medicine ?

[Maxone73 in reply to God_Loves_Me]

yes