64Cu-SAR-bisPSMA Is Safe and Highly Effective in Detecting Tumours in Prostate Cancer Patients: results from COBRA trial

[Maxone73]

This could mean being way more precise in finding micro metastasis and in guided surgery!

urotoday.com/recent-abstrac...

[God_Loves_Me]

clinicaltrials.gov/study/NC...

[Purple-Bike]

Indeed, this could be a game changer. E.g. wiping out smaller mets with SBRT.

[j-o-h-n]

I'd prefer "Detecting them, then Sucking and Spiting them out"........

Good Luck, Good Health and Good Humor.

j-o-h-n

[Maxone73 in reply to j-o-h-n]

You are referring to 64-CU-M8! then…

[j-o-h-n in reply to Maxone73]

Yep, and always remember Never Kiss them after........

Good Luck, Good Health and Good Humor.

j-o-h-n

[CousinGrandpa]

I was in that trial, and it found one small lesion. Zapped it with SBRT. PSA 0.02 now. No problems with the procedure at all. Thanks Doc Shore!

[Hidden in reply to CousinGrandpa]

At what psa level was this lesion detected?

[Maxone73 in reply to Hidden]

"The median PSA at study entry was 0.9 ng/mL (range 0.25 – 17.60). This PSA range was considerably lower than in the registrational studies for the approved PSMA PET agents in BCR. "

[CousinGrandpa]

I think it was 2.0

[Tony666]

Any idea what they mean by “next day” imaging? Is it that you are dosed with the solution, then go home, then come back the next day for the scan? Or something else?

[Maxone73 in reply to Tony666]

Hi! I suppose this: when you test any new drug/treatment you are assessing also its kinetic, like half-life time, total duration of its effects and so on (that's how they know for example that ARX517 is effective for 7-10 days instead of few hours). Testing this 64Cu-SAR-bisPSMA they realised that it works well the same day, but even better if you wait for 24 hours before the scan. Of course this has some implications, like for example that if you live far from the hospital you may need to sleep there or to find some accomodation, which is a limit, but the big plus is that it's very sensitive and could guide radiotherapy to micro metastasis.