What's different between Xtandi vs NUBEQA® (darolutamide) vs ERLEADA® (apalutamide)

[God_Loves_Me]

Hello Everyone,

zytiga didn’t work so move to xtandi

After two months, Xtandi did not work, and PSA started going up; I suggested to the doctor to prescribe other medicine ( NUBEQA® (darolutamide) or ERLEADA® (apalutamide) based on this group's recommendations.

Dr keeps telling me NO and tells me it is SAMETHING. Is it true?

DR RO is telling us to try NUBEQA® (darolutamide) or ERLEADA® (apalutamide), and Primary care oncology is saying NO. It is same thing

Anyone has similar experience?

[Tall_Allen]

IDK why you say it's "this group's recommendation." Please don't blame me for the bad advice others may give you. No one speaks for the group.

[KocoPr]

I would ask your doc what he recommends and go from there. There is nothing in your bio

[God_Loves_Me in reply to KocoPr]

Ye I am pretty new here. What's informations I should add in bio ?

[Sunlight12 in reply to God_Loves_Me]

Koco meant to add your treatment info to the Bio section of your account, but it looks like you've already done that. Good job! This forum is a fantastic resource - so much information and real life experiences, and so many willing to kindly share their experience. Keep researching/searching (you might try something like "Rising PSA" - that should bring up many posts where hopefully you can find a discussion(s) that reflect your experience), and asking questions! Sending healing energy your way!

In solidarity,

Sunlight

[Pinkyboy]

Based on several conversations with my medical oncologist, I understand the oral drugs you mentioned are not “the same.” In my case, NUBEQA was my MO’s choice. So far, so good.

[GP24]

These drugs work very similar but they are not "the same". You could try to use Erleada instead but it may not make a difference. If you have not had Abiraterone yet, you could take that drug. This works differently to the ones you mentioned. However, there is a cross-resistance with Xtandi. So if you had Abiraterone already, it is not unusual that Xtandi works just two months. You could get a genetic test now to see if you have a treatable mutation.

[God_Loves_Me]

I did tried zytiga and didn’t work so move to xtandi and now other medications

[God_Loves_Me]

genetic test negative

[GP24]

You could get Xofigo/Radium 223 against your bone mets. This treatment will work against bone mets but usually the PSA value keeps rising.

[God_Loves_Me]

there are 5 active lesions and getting SBRT radiation to kill them all in 5 session

And other lesions are inactive or showing no increase activity

[GP24 in reply to God_Loves_Me]

If you know an RO which will radiate that, go ahead. Many ROs will not treat when there are more than five mets.

[God_Loves_Me]

thank you and god bless you

[j-o-h-n]

FYI In April last year, my M.O. took me off of Casodex and replaced it with Nubeqa and it's working.

p.s. Hopefully he/she loves us all......

Good Luck, Good Health and Good Humor.

j-o-h-n

[CAMPSOUPS in reply to j-o-h-n]

You've been awhile on Nubequa john.Glad its working!

[j-o-h-n in reply to CAMPSOUPS]

Me too - thanks.... this is current Psa history:

P.S.A. 1.98 as of 12/30/22

P.S.A. 2.14 as of 02/20/23

P.S.A. 1.24 as of 04/03/23 Began Nubeqa

P.S.A. 1.49 as of 06/27/23

P.S.A. 1.26 as of 08/15/23

P.S.A. 0.80 as of 11/08/23

P.S.A. 0.72 as of 12/18/23

Good Luck, Good Health and Good Humor.

j-o-h-n

[Kevinski65]

Get on Celebrex, eat blueberries, take zyflamend for prostate, green tea, order 4-mu from Europe, arteminisin , pomegranate juice. Take alongside allopathic treatments . Resveratol and lycopene are good too.

[janebob99 in reply to Kevinski65]

What about cur cumin?

[Kevinski65 in reply to janebob99]

Yes that’s good too, but need to be

taken alongside allopathic therapy. It is included in zyflamend I think.

[janebob99]

Yes, Zyflamend is a good product.